3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate

Base Information

• Chemical Name: 3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate
• CAS No.: 1162655-06-2
• Molecular Formula: C₇H₈O₃S*C₂₂H₂₆N₂O₂S
• Molecular Weight: 554.731
• Mol file: 1162655-06-2.mol

Synonyms:3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate

Chemical Property of 3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate

There total 3 articles about 3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.76%

(R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate (1196663-24-7) + toluene-4-sulfonic acid (104-15-4) → 3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate (1162655-06-2)

Guidance literature:

(R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate; With methanesulfonic acid; hydrogen; palladium 10% on activated carbon; In water; acetone; at 8 - 10 ℃; under 1471.14 - 3677.86 Torr;

With ammonia; In methyl tert-butyl ether (MTBE); water; pH=9.0 - 9.5;

toluene-4-sulfonic acid; In ethanol; at 40 - 45 ℃;

Reference yield: 73.5%

(R)-5-[(2-phenylsulfonyl)ethenyl]-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole (180637-89-2) + toluene-4-sulfonic acid (104-15-4) → 3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate (1162655-06-2)

Guidance literature:

(R)-5-[(2-phenylsulfonyl)ethenyl]-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole; With methanesulfonic acid; hydrogen; palladium 10% on activated carbon; In water; acetone; at 8 - 10 ℃;

With ammonia; In water; pH=12;

toluene-4-sulfonic acid; In acetone; at 40 ℃; for 2h; pH=4.5 - 5.0; Product distribution / selectivity;

Reference yield: 60.0%

(R)-1-acetyl-5-(2-benzenesulphonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole (438226-82-5) + toluene-4-sulfonic acid (104-15-4) → 3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate (1162655-06-2)

Guidance literature:

(R)-1-acetyl-5-(2-benzenesulphonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole; With methanol; potassium carbonate; In acetone; at 20 - 25 ℃;

toluene-4-sulfonic acid; In acetone; at 35 - 40 ℃;

upstream raw materials:

(R)-1-acetyl-5-(2-benzenesulphonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole

toluene-4-sulfonic acid

(R)-5-[(2-phenylsulfonyl)ethenyl]-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole

(R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate

Downstream raw materials:

eletriptan

eletriptan hydrobromide

Refernces