(R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate

Base Information

• Chemical Name: (R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate
• CAS No.: 1196663-24-7
• Molecular Formula: CH₄O₃S*C₂₂H₂₄N₂O₂S
• Molecular Weight: 476.618
• Mol file: 1196663-24-7.mol

Synonyms:(R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate

Chemical Property of (R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate

There total 4 articles about (R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(R)-5-[(2-phenylsulfonyl)ethenyl]-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole (180637-89-2) + methanesulfonic acid (75-75-2,98527-29-8) → (R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate (1196663-24-7)

Guidance literature:

In acetone; at 30 - 35 ℃;

Reference yield:

(R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole (180637-88-1) + methanesulfonic acid (75-75-2,98527-29-8) → (R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate (1196663-24-7)

Guidance literature:

(R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole; With methanol; potassium carbonate; at 25 - 35 ℃;

methanesulfonic acid; In acetone; at 25 - 30 ℃; Product distribution / selectivity;

Reference yield:

C16H19BrN2O → (R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate (1196663-24-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 25 - 35 °C

1.2: 25 - 83 °C

2.1: potassium carbonate; methanol / 25 - 35 °C

2.2: 25 - 30 °C

With methanol; potassium carbonate; triethylamine; palladium diacetate; tris-(o-tolyl)phosphine; In acetonitrile;

upstream raw materials:

(R)-5-[(2-phenylsulfonyl)ethenyl]-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole

methanesulfonic acid

(R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole

5-bromo-3-(1-methylpyrrolidin-2(R)-ylmethyl)-1H-indole

Downstream raw materials:

3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate

(R)-5-(2-phenylsulphonylethyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate

Refernces

• 1、 -. "Salts of (R)-5-(2phenylsulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole, 5-bromo-3-[(R)-1-methyl-pyrrolidin-2-ylmethyl]-1H-indole and of eletriptan". Page/Page column 7. . Retrieved 2009/12/23.