4-chlorophenyl 4-chlorobenzoate

Base Information

• Chemical Name: 4-chlorophenyl 4-chlorobenzoate
• CAS No.: 6961-42-8
• Molecular Formula: C13H8 Cl2 O2
• Molecular Weight: 267.111
• Mol file: 6961-42-8.mol

Synonyms:Benzoicacid, p-chloro-, p-chlorophenyl ester (6CI,8CI); 4-Chlorophenyl4-chlorobenzoate; NSC 63164; p-Chlorophenyl p-chlorobenzoate

Chemical Property of 4-chlorophenyl 4-chlorobenzoate

Chemical Property:

• Vapor Pressure: 4.4E-06mmHg at 25°C
• Boiling Point: 383.4°Cat760mmHg
• Flash Point: 160°C
• Density: 1.357g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chlorophenyl 4-chlorobenzoate

There total 7 articles about 4-chlorophenyl 4-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-chloro-phenol (106-48-9,82344-39-6) + para-chlorobenzoic acid (74-11-3) → 4-chlorophenyl 4-chlorobenzoate (6961-42-8)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.5012/bkcs.2012.33.6.1939

Reference yield: 95.0%

4-Chlorophenylboronic acid (1679-18-1) + 4-chlorobenzaldehyde (104-88-1) → 4-chlorophenyl 4-chlorobenzoate (6961-42-8)

Guidance literature:

With oxygen; caesium carbonate; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; In toluene; at 60 ℃; for 6h; Air atmosphere;

DOI:10.1039/c1ob06566a

Reference yield:

chlorobenzene (108-90-7) → 1-Chloro-4-iodobenzene (637-87-6) + 4-chlorophenyl 4-chlorobenzoate (6961-42-8)

Guidance literature:

With iodine;

upstream raw materials:

4-chloro-benzoyl chloride

4-chloro-phenol

para-chlorobenzoic acid

4-nitrophenyl 4-chlorobenzoate

Downstream raw materials:

4-chlorophenyl benzoate

4-[2-(4-chlorophenyl)-2-oxoethyl]benzonitrile

4-chlorophenyl nonanate

[5-chloro-2-(4-nitro-benzyloxy)-phenyl] (4-chloro-phenyl) methanone

Refernces

• 1、 Kwon, Eun Mi,Kim, Cheol Gi,Goh, Ah Ra,Park, Jinseu,Jun, Jong-Gab. "Preparation of benzoyloxy benzophenone derivatives and their inhibitory effects of ICAM-1 expression". experimental part. p. 1939 - 1944. Retrieved 2012/08/07.
• 2、 Neetha,Venu,Sridhar,Prasad, J. Shashidhara,Shashikanth. "Synthesis and crystal structure of [5-Chloro-2-(4-nitro-benzyloxy)-phenyl]- (4-chloro-phenyl) methanone". experimental part. p. 151 - 158. Retrieved 2010/08/05.