4-nitrobenzyl 3-phenyl-2-aminopropionate

Base Information

• Chemical Name: 4-nitrobenzyl 3-phenyl-2-aminopropionate
• CAS No.: 7413-82-3
• Molecular Formula: C₁₆H₁₆N₂O₄
• Molecular Weight: 300.314
• Mol file: 7413-82-3.mol

Synonyms:4-nitrobenzyl 3-phenyl-2-aminopropionate

Chemical Property of 4-nitrobenzyl 3-phenyl-2-aminopropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-nitrobenzyl 3-phenyl-2-aminopropionate

There total 2 articles about 4-nitrobenzyl 3-phenyl-2-aminopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(tert-butoxycarbonylamino)-3-phenylpropionic acid (4530-18-1) + 4-nitrobenzyl chloride (100-14-1) → 4-nitrobenzyl 3-phenyl-2-aminopropionate (7413-82-3)

Guidance literature:

2-(tert-butoxycarbonylamino)-3-phenylpropionic acid; 4-nitrobenzyl chloride; With caesium carbonate;

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.ijms.2014.05.011

Reference yield:

→ 4-nitrobenzyl 3-phenyl-2-aminopropionate (7413-82-3)

Guidance literature:

Phenylalamin, p-Nitrobenzylbromid.;

Reference yield: 89.0%

4-nitrobenzyl 3-phenyl-2-aminopropionate (7413-82-3) + Chlorameisensaeure-N-5-hydroxy-norbornen-2,3-dicarboximidester (99502-89-3) → N-hydroxy-5-norbomene-2,3-dicarboxylic acid imide (1195164-50-1,397299-61-5) + 2-((1S,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yloxycarbonylamino)-3-phenyl-propionic acid 4-nitro-benzyl ester (102609-49-4)

Guidance literature:

With triethylamine; In dichloromethane; at -5 ℃; for 0.5h;

upstream raw materials:

2-(tert-butoxycarbonylamino)-3-phenylpropionic acid

4-nitrobenzyl chloride

Downstream raw materials:

N-hydroxy-5-norbomene-2,3-dicarboxylic acid imide

2-((1S,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yloxycarbonylamino)-3-phenyl-propionic acid 4-nitro-benzyl ester

2-{3-[1-(4-Nitro-benzyloxycarbonyl)-2-phenyl-ethyl]-ureido}-3-phenyl-propionic acid 4-nitro-benzyl ester

Refernces

• 1、 -. "FUSED TRICYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY". . . Retrieved 2008/06/13.