N-hydroxy-5-norbomene-2,3-dicarboxylic acid imide

Base Information

• Chemical Name: N-hydroxy-5-norbomene-2,3-dicarboxylic acid imide
• CAS No.: 1195164-50-1
• Molecular Formula: C₉H₉NO₃
• Molecular Weight: 179.175
• Mol file: 1195164-50-1.mol

Synonyms:N-hydroxy-5-norbomene-2,3-dicarboxylic acid imide

Chemical Property of N-hydroxy-5-norbomene-2,3-dicarboxylic acid imide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-hydroxy-5-norbomene-2,3-dicarboxylic acid imide

There total 15 articles about N-hydroxy-5-norbomene-2,3-dicarboxylic acid imide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

morpholine (110-91-8,99108-56-2) + Chlorameisensaeure-N-5-hydroxy-norbornen-2,3-dicarboximidester (99502-89-3) → N-hydroxy-5-norbomene-2,3-dicarboxylic acid imide (1195164-50-1,397299-61-5) + Morpholine-4-carboxylic acid (1S,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl ester (121820-06-2)

Guidance literature:

With triethylamine; In dichloromethane; at -5 ℃; for 0.5h;

Reference yield: 89.0%

4-nitrobenzyl 3-phenyl-2-aminopropionate (7413-82-3) + Chlorameisensaeure-N-5-hydroxy-norbornen-2,3-dicarboximidester (99502-89-3) → N-hydroxy-5-norbomene-2,3-dicarboxylic acid imide (1195164-50-1,397299-61-5) + 2-((1S,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yloxycarbonylamino)-3-phenyl-propionic acid 4-nitro-benzyl ester (102609-49-4)

Guidance literature:

With triethylamine; In dichloromethane; at -5 ℃; for 0.5h;

Reference yield: 87.0%

DL-Leucin-(4-nitro-benzylester) (7352-67-2) + Chlorameisensaeure-N-5-hydroxy-norbornen-2,3-dicarboximidester (99502-89-3) → N-hydroxy-5-norbomene-2,3-dicarboxylic acid imide (1195164-50-1,397299-61-5) + 2-((1S,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yloxycarbonylamino)-4-methyl-pentanoic acid 4-nitro-benzyl ester (102609-47-2)

Guidance literature:

With triethylamine; In dichloromethane; at -5 ℃; for 0.5h;

upstream raw materials:

pyrrolidine

Chlorameisensaeure-N-5-hydroxy-norbornen-2,3-dicarboximidester

morpholine

phenylalanine ethyl ester

Downstream raw materials:

N-benzyloxycarbonyloxy-5-norebornene-endo-2,3-dicarboximide

(N-hydroxy-5-norbornene-2,3-dicarboxyl-imido)-N-PNZ-4-amino-2(S)-hydroxy-butanoate

N-(4-nitrobenzyl carbonate)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid imide

Refernces