Thiazolidine

Base Information

• Chemical Name: Thiazolidine
• CAS No.: 504-78-9
• Molecular Formula: C3H7NS
• Molecular Weight: 89.1613
• Hs Code.: 29341000
• European Community (EC) Number: 208-002-5
• NSC Number: 357911
• UNII: I320806BKW
• DSSTox Substance ID: DTXSID10198447
• Nikkaji Number: J149.955F
• Wikipedia: Thiazolidine
• Wikidata: Q413761
• Metabolomics Workbench ID: 57336
• ChEMBL ID: CHEMBL1916078
• Mol file: 504-78-9.mol

Synonyms:Thiazolidine;Thiazolidines

Chemical Property of Thiazolidine

Chemical Property:

• Appearance/Colour: clear colorless liquid
• Vapor Pressure: 1.96mmHg at 25°C
• Refractive Index: n20/D 1.5508(lit.)
• Boiling Point: 164.5 °C at 760 mmHg
• PKA: 8.84±0.20(Predicted)
• Flash Point: 56.1 °C
• PSA: 37.33000
• Density: 1.058 g/cm³
• LogP: 0.60910
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 89.02992040
• Heavy Atom Count: 5
• Complexity: 30.1

Purity/Quality:

Thiazolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 45-36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CSCN1
• Recent NIPH Clinical Trials: Japan Prospective Long Term Clinical Trial in Type 2 Diabetes Patients with Sulfonyl Urea and Sitagliptin
• Uses: Thiazolidine was used in the synthesis of homogeneous penicillamine disulphide cross-linked polypeptides.

Technology Process of Thiazolidine

There total 9 articles about Thiazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

→ 1,3-thiazolidine (504-78-9) + (4-R)-2-(pyridin-3-yl)thiazolidine-4-carboxylic acid (59777-95-6)

Guidance literature:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-mercaptoethylamine hydrochloride (156-57-0) → 1,3-thiazolidine (504-78-9)

Guidance literature:

DOI:10.1021/ja01280a050

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + Cysteamine (60-23-1) → 1,3-thiazolidine (504-78-9)

Guidance literature:

With phosphate buffer; In water; at 25 ℃; for 0.5h;

DOI:10.1021/jf9705633

upstream raw materials:

formaldehyd

2-mercaptoethylamine hydrochloride

Cysteamine

Downstream raw materials:

3-(4-nitro-benzenesulfonyl)-thiazolidine

3-(4-acetoxy-3,5-dimethoxy-benzoyl)-thiazolidine

3-(3,4,5-Trimethoxybenzoyl)thiazolidin

2-(methylamino)ethanethiol

Refernces

• 1、 Yu,Wen,Feng,Bi,Wang,Peng,Sheng,Fu. "Development of a compound-specific carbon isotope analysis method for atmospheric formaldehyde via NaHSO3 and cysteamine derivatization". . p. 1206 - 1211. Retrieved 2006.
• 2、 -. "Process for the preparation of teneligliptin". Page/Page column 24. . Retrieved 2017/01/02.