2-(3-PIRIDYL)THIAZOLIDINE-4-CARBOXYLIC ACID

Base Information

• Chemical Name: 2-(3-PIRIDYL)THIAZOLIDINE-4-CARBOXYLIC ACID
• CAS No.: 59777-95-6
• Molecular Formula: C9H10N2O2S
• Molecular Weight: 210.257
• Hs Code.: 2934999090
• Mol file: 59777-95-6.mol

Synonyms:4-Thiazolidinecarboxylicacid, 2-(3-pyridyl)- (6CI);2-(3-Pyridyl)-4-carboxythiazolidine;2-Pyridin-3-yl-1,3-thiazolidine-4-carboxylic acid;NSC 303514;

Chemical Property of 2-(3-PIRIDYL)THIAZOLIDINE-4-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 1.43E-09mmHg at 25°C
• Refractive Index: 1.619
• Boiling Point: 468.2 °C at 760 mmHg
• Flash Point: 237 °C
• PSA: 87.52000
• Density: 1.366 g/cm³
• LogP: 1.19860

Purity/Quality:

98%min ^*data from raw suppliers

2-(3-Piridyl)thiazolidine-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(3-Piridyl)thiazolidine-4-carboxylic Acid can be used as antiallergics and PAF antagonists.

Technology Process of 2-(3-PIRIDYL)THIAZOLIDINE-4-CARBOXYLIC ACID

There total 4 articles about 2-(3-PIRIDYL)THIAZOLIDINE-4-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

→ 1,3-thiazolidine (504-78-9) + (4-R)-2-(pyridin-3-yl)thiazolidine-4-carboxylic acid (59777-95-6)

Guidance literature:

Reference yield: 81.0%

3-pyridinecarboxaldehyde (500-22-1) + L-Cysteine (52-90-4) → (2RS,4R)-2-(pyridin-3-yl)-4-thiazolidine-carboxylic acid (59777-95-6)

Guidance literature:

In ethanol; water; at 100 ℃; for 5h;

DOI:10.1021/jm00039a015

Reference yield:

3-pyridinecarboxaldehyde (500-22-1) + l-cysteine hydrochloride (52-89-1) → (2RS,4R)-2-(pyridin-3-yl)-4-thiazolidine-carboxylic acid (59777-95-6)

Guidance literature:

With potassium acetate; In methanol; water; at 20 ℃; for 5h;

upstream raw materials:

3-pyridinecarboxaldehyde

rac-cysteine

L-Cysteine

l-cysteine hydrochloride

Refernces

• 1、 Gududuru, Veeresa,Hurh, Eunju,Dalton, James T.,Miller, Duane D.. "Discovery of 2-arylthiazolidine-4-carboxylic acid amides as a new class of cytotoxic agents for prostate cancer". . p. 2584 - 2588. Retrieved 2007/10/03.
• 2、 Suzuki, Takeshi,Nagaoka, Hitoshi,Kondo, Yutaka,Takahashi, Takumi,Takeuchi, Makoto,Hara, Hiromu,Saito, Munetoshi,Yamada, Toshimitsu,Tomioka, Kenichi,Hamada, Mamoru,Mase, Toshiyasu. "2-(3-pyridyl)thiazolidine-4-carboxamide derivatives. II. Structure- activity relationships and active configuration of 2-(3- pyridyl)thiazolidine-4-carboxamides as platelet-activating factor receptor antagonists". . p. 1468 - 1473. Retrieved 2007/10/03.