1,1-Diphenyl-2-propanol

Base Information

• Chemical Name: 1,1-Diphenyl-2-propanol
• CAS No.: 29338-49-6
• Molecular Formula: C₁₅H₁₆O
• Molecular Weight: 212.291
• Hs Code.: 29062900
• European Community (EC) Number: 249-574-6
• NSC Number: 244476
• DSSTox Substance ID: DTXSID501031184
• Nikkaji Number: J150.093G
• Mol file: 29338-49-6.mol

Synonyms:1,1-Diphenyl-2-propanol;1,1-diphenylpropan-2-ol;29338-49-6;EINECS 249-574-6;alpha-Methyl-beta-phenylphenethyl alcohol;Benzeneethanol, alpha-methyl-beta-phenyl-;NSC244476;3-diphenylpropan-2-ol;SCHEMBL5873452;C(C(C)O)(c1ccccc1)c2ccccc2;DTXSID501031184;AKOS000249591;NSC 244476;NSC-244476;FT-0717729;Benzeneethanol, .alpha.-methyl-.beta.-phenyl-;5-(1-NAPHTHYL)THIOPHENE-2-CARBOXYLICACID

Chemical Property of 1,1-Diphenyl-2-propanol

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 7.36E-05mmHg at 25°C
• Melting Point: 59-62 °C(lit.)
• Refractive Index: 1.575
• Boiling Point: 329 °C at 760 mmHg
• Flash Point: 135.3 °C
• PSA: 20.23000
• Density: 1.058 g/cm³
• LogP: 3.19930
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 212.120115130
• Heavy Atom Count: 16
• Complexity: 172

Purity/Quality:

99.5% ^*data from raw suppliers

1,1-Diphenyl-2-propanol ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(C1=CC=CC=C1)C2=CC=CC=C2)O

Technology Process of 1,1-Diphenyl-2-propanol

There total 39 articles about 1,1-Diphenyl-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,1-diphenylacetone (781-35-1) → (R)-(+)-1,1-diphenylpropan-2-ol (29338-49-6,41997-47-1,52225-24-8,52199-85-6)

Guidance literature:

With carbonylhydridotris(triphenylphosphine)iridium(I); N,N'-bis[o-(diphenylphosphino)benzylidene]-(1S,2S)-diaiminocyclohexane; In isopropyl alcohol; at 75 ℃; for 8.5h;

DOI:10.1021/ol047412n

Reference yield: 90.0%

1,1-diphenylacetone (781-35-1) → (S)-(-)-1,1-diphenylpropan-2-ol (29338-49-6,52199-85-6,52225-24-8,41997-47-1)

Guidance literature:

[IrHCl₂(cod)]2; N,N'-bis[o-(diphenylphosphino)benzylidene]-(1S,2S)-diaiminocyclohexane; In isopropyl alcohol; at 20 ℃; for 17h;

DOI:10.1016/j.tetlet.2004.09.088

Reference yield: 76.0%

1,1-diphenyl-1-propene (778-66-5) → 1,1-diphenyl-2-propanol (41997-47-1,52199-85-6,52225-24-8,29338-49-6)

Guidance literature:

With water; diphenyldisulfane; 9-(2-mesityl)-10-methylacridinium perchlorate; In acetonitrile; at 20 ℃; for 24h; regioselective reaction; Irradiation; Inert atmosphere;

DOI:10.1021/acscatal.6b03388

upstream raw materials:

methyl magnesium iodide

Diphenylacetaldehyde

1,1-diphenylacetone

ethanol

Downstream raw materials:

(+/-)-phthalic acid mono-(1-methyl-2,2-diphenyl-ethyl ester)

(1S,2S)-1-chloro-1,2-diphenyl-propane

1,2-diphenylpropene

(S)-(-)-1,1-diphenylpropan-2-ol

Refernces

• 1、 Meyer, Kevin G.,Bravo-Altamirano, Karla,Herrick, Jessica,Loy, Brian A.,Yao, Chenglin,Nugent, Ben,Buchan, Zachary,Daeuble, John F.,Heemstra, Ron,Jones, David M.,Wilmot, Jeremy,Lu, Yu,DeKorver, Kyle,DeLorbe, Johnathan,Rigoli, Jared. "Discovery of florylpicoxamid, a mimic of a macrocyclic natural product". . . Retrieved 2021/11/08.
• 2、 Beller, Matthias,Junge, Kathrin,Leischner, Thomas,Li, Wu,Liu, Weiping. "A General Regioselective Synthesis of Alcohols by Cobalt-Catalyzed Hydrogenation of Epoxides". . p. 11321 - 11324. Retrieved 2020/05/16.