Multi-step reaction with 4 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
2.1: sodium t-butanolate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0) / isopropyl alcohol; toluene / 100 °C / Inert atmosphere
2.2: 1 h / 20 °C
3.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium(0); 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere
4.1: potassium carbonate / N,N-dimethyl-formamide; water / Reflux
With
sodium hexamethyldisilazane; potassium carbonate; potassium hydroxide; sodium t-butanolate;
2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;