Technology Process of <2-methyl-5-(naphth-2-ylmethoxy)phenyl>thiazol-2-ylmethanone
There total 4 articles about <2-methyl-5-(naphth-2-ylmethoxy)phenyl>thiazol-2-ylmethanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 64 percent / 5.4 volpercent H2SO4, aq. NaNO2 / 0.5 h / Heating
2: 89 percent / K2CO3 / dimethylformamide / 18 h / Ambient temperature
3: 1.) n-BuLi / 1.) ether, hexane, -70 deg C, 0.5 h, 2.) THF, ether, hexane, -70 deg C, 0.5 h
With
n-butyllithium; sulfuric acid; potassium carbonate; sodium nitrite;
In
N,N-dimethyl-formamide;
DOI:10.1021/jm00111a038
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 94 percent / H2 / 10percent Pd/C / ethanol / 2 h / 1520 - 2280 Torr
2: 64 percent / 5.4 volpercent H2SO4, aq. NaNO2 / 0.5 h / Heating
3: 89 percent / K2CO3 / dimethylformamide / 18 h / Ambient temperature
4: 1.) n-BuLi / 1.) ether, hexane, -70 deg C, 0.5 h, 2.) THF, ether, hexane, -70 deg C, 0.5 h
With
n-butyllithium; sulfuric acid; hydrogen; potassium carbonate; sodium nitrite;
palladium on activated charcoal;
In
ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00111a038
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 89 percent / K2CO3 / dimethylformamide / 18 h / Ambient temperature
2: 1.) n-BuLi / 1.) ether, hexane, -70 deg C, 0.5 h, 2.) THF, ether, hexane, -70 deg C, 0.5 h
With
n-butyllithium; potassium carbonate;
In
N,N-dimethyl-formamide;
DOI:10.1021/jm00111a038
