2-(Furan-2-yl)pyrrolidine

Base Information

• Chemical Name: 2-(Furan-2-yl)pyrrolidine
• CAS No.: 90086-89-8
• Molecular Formula: C8H11 N O
• Molecular Weight: 137.181
• Hs Code.: 2934999090
• European Community (EC) Number: 837-900-5
• DSSTox Substance ID: DTXSID60394917
• Metabolomics Workbench ID: 48798
• ChEMBL ID: CHEMBL461087
• Mol file: 90086-89-8.mol

Synonyms:2-(furan-2-yl)pyrrolidine;90086-89-8;2-(2-furyl)pyrrolidine;2-Furan-2-yl-pyrrolidine;2-(2-Furanyl)pyrrolidine;Pyrrolidine, 2-(2-furyl)-;CHEMBL461087;MFCD02663415;2-(2-Furyl)pyrrolidine;2-(Furan-2-yl)pyrrolidine;2-(Fur-2-yl)pyrrolidine;2-(uran-2-yl)pyrrolidine;Oprea1_525509;SCHEMBL2349663;(RS)-2-furan-2-yl-pyrrolidine;DTXSID60394917;CHEBI:173242;(+/-)-2-(2-Furanyl)pyrrolidine;BBL020479;BDBM50412416;STK134526;AKOS005168094;PS-3493;SB61175;(S)-5-AMINOMETHYLPYRROLIDIN-2-ONE;BB 0249484;FT-0642156;EN300-74367;A26468;N12240;Z281773792

Chemical Property of 2-(Furan-2-yl)pyrrolidine

Chemical Property:

• Vapor Pressure: 0.22mmHg at 25°C
• Boiling Point: 207.9 °C at 760 mmHg
• PKA: 10.13±0.10(Predicted)
• Flash Point: 79.5 °C
• PSA: 25.17000
• Density: 1.041g/cm³
• LogP: 2.03290
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 116

Purity/Quality:

98%min ^*data from raw suppliers

2-(furan-2-yl)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(NC1)C2=CC=CO2

Technology Process of 2-(Furan-2-yl)pyrrolidine

There total 4 articles about 2-(Furan-2-yl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(furan-2-yl)-4-oxobutanenitrile (17960-37-1) → 2-(furan-2-yl)pyrrolidine (90086-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Raney-Ni / methanol

2: LiAlH₄ / diethyl ether / 4 h / Heating

With lithium aluminium tetrahydride; hydrogen; nickel; In methanol; diethyl ether;

Reference yield:

1-pyrroline (5724-81-2) + furan (110-00-9) → 2-(furan-2-yl)pyrrolidine (90086-89-8)

Guidance literature:

furan; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 0.666667h; Inert atmosphere;

1-pyrroline; With boron trifluoride diethyl etherate; In tetrahydrofuran; diethyl ether; hexane; at -78 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jacs.9b04325

Reference yield:

5-(2-furanyl)-1-pyrroline (502546-17-0) → 2-(furan-2-yl)pyrrolidine (90086-89-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 4h; Heating;

upstream raw materials:

5-(2-furanyl)-1-pyrroline

2,2,5,5-tetrametyl-1-aza-2,5-disilacyclopentane-1-propyl magnesium bromide

N-methoxy-N-methyl-2-furancarboxamide

4-(furan-2-yl)-4-oxobutanenitrile

Downstream raw materials:

3'-[(2-amino-2-benzyl-3-hydroxypropoxy)methyl]-5'-{[2-(2-furyl)pyrrolidin-1-yl]carbonyl}-1,1'-biphenyl-2-carbonitrile

Refernces

• 1、 Basha, Fatima Z.,DeBernardis, John F.. "A NOVEL THREE CARBON-AMINO GRIGNARD REAGENT: ITS USE IN AN EFFICIENT PYRROLIDINE SYNTHESIS". . p. 5271 - 5274. Retrieved 2007/10/02.