4-Amino-n-[2-(diethylamino)ethyl]-2-methoxybenzamide

Base Information Edit

Chemical Name:4-Amino-n-[2-(diethylamino)ethyl]-2-methoxybenzamide
CAS No.:3761-48-6
Molecular Formula:C14H23 N3 O2
Molecular Weight:265.356
Hs Code.:2924299090
European Community (EC) Number:223-177-8
DSSTox Substance ID:DTXSID40191047
Nikkaji Number:J217.656D
Wikidata:Q83063532
Mol file:3761-48-6.mol

Synonyms:3761-48-6;4-amino-n-[2-(diethylamino)ethyl]-2-methoxybenzamide;4-Amino-N-(2-(diethylamino)ethyl)-2-methoxybenzamide;EINECS 223-177-8;Benzamide,4-amino-N-[2-(diethylamino)ethyl]-2-methoxy-;C14H23N3O2;SCHEMBL1185641;DTXSID40191047;AKOS019279605;EN300-113729;N-(2-diethylaminoethyl) 4-amino-2-methoxybenzamide;4-amino-N-(2-diethylamino-ethyl)-2-methoxy-benzamide;Benzamide, 4-amino-N-(2-(diethylamino)ethyl)-2-methoxy-

Suppliers and Price of 4-Amino-n-[2-(diethylamino)ethyl]-2-methoxybenzamide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Amino-N-(2-(diethylamino)ethyl)-2-methoxybenzamide
100mg
$ 125.00

AK Scientific
4-Amino-n-[2-(diethylamino)ethyl]-2-methoxybenzamide
250mg
$ 361.00

Total 7 raw suppliers

Chemical Property of 4-Amino-n-[2-(diethylamino)ethyl]-2-methoxybenzamide Edit

Chemical Property:

Vapor Pressure:9.95E-08mmHg at 25°C
Boiling Point:433.8°C at 760 mmHg
PKA:14.38±0.46(Predicted)
Flash Point:216.2°C
PSA：71.08000
Density:1.079g/cm³
LogP:2.50500
XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:265.17902698
Heavy Atom Count:19
Complexity:269

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-N-(2-(diethylamino)ethyl)-2-methoxybenzamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)CCNC(=O)C1=C(C=C(C=C1)N)OC
Uses 4-Amino-N-(2-(diethylamino)ethyl)-2-methoxybenzamide is used in the synthesis of radioiodinated MIP-1145 as a therapy of melanoma.

Technology Process of 4-Amino-n-[2-(diethylamino)ethyl]-2-methoxybenzamide

There total 14 articles about 4-Amino-n-[2-(diethylamino)ethyl]-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.3%

: 476615-23-3
N-(2-diethylamino-ethyl)-4-nitro-2-methoxybenzamide

: 3761-48-6
1112JDO

Guidance literature:: With palladium 10% on activated carbon; ammonium formate; In tetrahydrofuran; ethanol; for 1h; Inert atmosphere;
DOI:10.1002/jlcr.3415

Reference yield: 74.0%

: 3614-38-8
4-acetamido-N-(2-(diethylamino)ethyl)-2-methoxybenzamide

: 3761-48-6
1112JDO

Guidance literature:: With potassium hydroxide; In methanol; water;
DOI:10.1021/jm0701627

Reference yield:

: 2597-56-0
4-nitro-o-anisic acid

: 3761-48-6
1112JDO

Guidance literature:: Multi-step reaction with 2 steps

1: [O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium]*BF₄; N,N-diisopropylethylamine / dimethylformamide / 2 h / 20 °C

2: H₂ / Pd/C / methanol / 4 h / 20 °C / atmospheric pressure

With hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm049637+