methyl 2-methyl-2-(4-(2-(methylsulfonyloxy)ethyl)phenyl)propanoate

Base Information

• Chemical Name: methyl 2-methyl-2-(4-(2-(methylsulfonyloxy)ethyl)phenyl)propanoate
• CAS No.: 1181267-32-2
• Molecular Formula: C₁₄H₂₀O₅S
• Molecular Weight: 300.376
• Mol file: 1181267-32-2.mol

Synonyms:methyl 2-methyl-2-(4-(2-(methylsulfonyloxy)ethyl)phenyl)propanoate

Chemical Property of methyl 2-methyl-2-(4-(2-(methylsulfonyloxy)ethyl)phenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-methyl-2-(4-(2-(methylsulfonyloxy)ethyl)phenyl)propanoate

There total 3 articles about methyl 2-methyl-2-(4-(2-(methylsulfonyloxy)ethyl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methyl-2-(4-(2-hydroxyethyl)phenyl)propionic acid methyl ester (1000536-33-3) + methanesulfonyl chloride (124-63-0) → methyl 2-methyl-2-(4-(2-(methylsulfonyloxy)ethyl)phenyl)propanoate (1181267-32-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

methyl 2-(4-bromophenyl)-2,2-dimethylacetate (154825-97-5) → methyl 2-methyl-2-(4-(2-(methylsulfonyloxy)ethyl)phenyl)propanoate (1181267-32-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride / N,N-dimethyl-formamide / 16 h / Reflux; Inert atmosphere

2.1: dimethylsulfide borane complex / tetrahydrofuran / 0 - 20 °C

2.2: 0 - 20 °C

3.1: triethylamine / toluene / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylsulfide borane complex; triethylamine; lithium chloride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 1.1: Stille coupling;

DOI:10.1080/00397911.2010.486506

Reference yield:

methanesulfonyl chloride (124-63-0) + methyl 2-(4-bromophenyl)-2,2-dimethylacetate (154825-97-5) → methyl 2-methyl-2-(4-(2-(methylsulfonyloxy)ethyl)phenyl)propanoate (1181267-32-2)

Guidance literature:

methyl 2-(4-bromophenyl)-2,2-dimethylacetate; vinyl derivative; With tetrakis(triphenylphosphine) palladium⁽⁰⁾;

With dihydrogen peroxide; sodium hydroxide;

methanesulfonyl chloride; With N-ethyl-N,N-diisopropylamine;

DOI:10.2174/1570178615666180402123643

upstream raw materials:

2-methyl-2-(4-(2-hydroxyethyl)phenyl)propionic acid methyl ester

methanesulfonyl chloride

methyl 2-(4-bromophenyl)-2,2-dimethylacetate

Downstream raw materials:

2-(4-{2-[4-(1H-benzoimidazol-2-yl)-piperidin-1-yl]-ethyl}phenyl)-2-methyl-propionic acid methyl ester

4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester

Bilastine

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS". Page/Page column 5. . Retrieved 2011/02/15.
• 2、 -. "PROCESS FOR PREPARATION OF 2-METHYL-2′-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS". Page/Page column 15. . Retrieved 2009/10/09.