2-Fluoroethanamine;hydron;chloride

Base Information

• Chemical Name: 2-Fluoroethanamine;hydron;chloride
• CAS No.: 460-08-2
• Molecular Formula: C2H7ClFN
• Molecular Weight: 99.5357
• Hs Code.: 2921199090
• Mol file: 460-08-2.mol

Synonyms:

Chemical Property of 2-Fluoroethanamine;hydron;chloride

Chemical Property:

• Vapor Pressure: 269mmHg at 25°C
• Melting Point: 99-103 °C(lit.)
• Refractive Index: 1.345
• Boiling Point: 52.1 °C at 760 mmHg
• Flash Point: 20.7 °C
• PSA: 26.02000
• Density: 0.892g/cm³
• LogP: 1.41690
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Hygroscopic
• Water Solubility.: Soluble in water
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 99.0251051
• Heavy Atom Count: 5
• Complexity: 10

Purity/Quality:

98%, ^*data from raw suppliers

2-Fluoroethylamine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: [H+].C(CF)N.[Cl-]
• Uses: 2-Fluoroethylamine hydrochloride may be used in the synthesis of the following:2-fluoroethylisocyanate1,3-bis-(2-fluoroethyl) urea (BFU)N-2-fluoroethylmaleimide[Cu4(O)(Ln)2(CH3COO)4] where HL= 4-methyl-2,6-bis(2-fluoroethyliminomethyl) phenol1-O-(4-(2-fluoroethyl-carbamoyloxymethyl)-2-nitrophenyl)-O-β-D-glucopyronuronate (FEAnGA)

Technology Process of 2-Fluoroethanamine;hydron;chloride

There total 5 articles about 2-Fluoroethanamine;hydron;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(2-fluoroethyl)isoindoline-1,3-dione (442-31-9) → 2-fluoroethylamine hydrochloride (460-08-2)

Guidance literature:

2-(2-fluoroethyl)isoindoline-1,3-dione; With hydrazine hydrate; In ethanol; at 50 ℃; for 9h;

With hydrogenchloride; In ethanol; water; for 1h; pH=5; Reflux;

Reference yield: 88.0%

1-azido-2-fluoroethane (894792-94-0) → 2-fluoroethylamine hydrochloride (460-08-2)

Guidance literature:

1-azido-2-fluoroethane; With 1,3-diphenyl-disiloxane; triphenylphosphine; at 20 ℃; for 24h;

With water;

With hydrogenchloride; In 1,4-dioxane; chemoselective reaction;

DOI:10.1021/acs.joc.9b00831

Reference yield:

2-fluoroethanol (371-62-0) → 2-fluoroethylamine hydrochloride (460-08-2)

Guidance literature:

2-fluoroethanol; With p-toluenesulfonyl chloride; at 90 ℃; for 5h;

With potassium phtalimide; In N,N-dimethyl-formamide; at 80 ℃; for 0.5h; Temperature; Further stages;

upstream raw materials:

N-<β-Fluor-ethyl>-B,B-difluor-borazan

2-fluoroethanol

1-azido-2-fluoroethane

2-(2-fluoroethyl)isoindoline-1,3-dione

Downstream raw materials:

4-[3-(2-Fluoro-ethyl)-ureido]-cyclohexanecarboxylic acid

1-cyclohexyl-3-(2-fluoroethyl)thiourea

1-(2-chloroethyl)-3-(2-fluoroethyl) urea

1,3-bis-(2-fluoroethyl) urea

Refernces

• 1、 Lenstra, Danny C.,Wolf, Joris J.,Mecinovi?, Jasmin. "Catalytic Staudinger Reduction at Room Temperature". . p. 6536 - 6545. Retrieved 2019/05/24.
• 2、 -. "2-fluoro ethylamine hydrochloride method for the preparation of". Paragraph 0031. . Retrieved 2017/06/02.