trans-2-methylcyclohexanol

Base Information

• Chemical Name: trans-2-methylcyclohexanol
• CAS No.: 15963-37-8
• Molecular Formula: C₇H₁₄O
• Molecular Weight: 114.188
• Mol file: 15963-37-8.mol

Synonyms:trans-2-methylcyclohexanol

Chemical Property of trans-2-methylcyclohexanol

Chemical Property:

• Boiling Point: 166.5±0.0 °C(Predicted)
• Density: 0.925±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of trans-2-methylcyclohexanol

There total 58 articles about trans-2-methylcyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Octanoic acid (1R,2S)-2-methyl-cyclohexyl ester (181962-57-2,15287-82-8) → (1R,2S)-2-methylcyclohexanol (583-59-5,615-38-3,615-39-4,7443-52-9,7443-70-1,15963-35-6,15963-37-8,19043-02-8,19043-03-9)

Guidance literature:

With potassium hydroxide; In methanol;

DOI:10.1021/ja961682m

Reference yield: 65.0%

2-Methylcyclohexanone (583-60-8) → (1R,2S)-2-methylcyclohexanol (583-59-5,615-38-3,615-39-4,7443-52-9,7443-70-1,15963-35-6,15963-37-8,19043-02-8,19043-03-9) + cis-2-methylcyclohexan-1-ol (15963-35-6) + trans-2-methylcyclohexanol (15963-37-8)

Guidance literature:

With Ficus benjamina callus cells; Gamborg's B-5 basal salt; chloramphenicol; 6-furfurylaminopurine; Sucrose; In ethanol; water; for 192h;

DOI:10.1016/j.tetasy.2006.07.029

Reference yield: 65.0%

2-Methylcyclohexanone (583-60-8) → (1R,2S)-2-methylcyclohexanol (583-59-5,615-38-3,615-39-4,7443-52-9,7443-70-1,15963-35-6,15963-37-8,19043-02-8,19043-03-9) + cis-2-methylcyclohexan-1-ol (15963-35-6) + trans-2-methylcyclohexanol (15963-37-8)

Guidance literature:

With Ficus benjamina callus cells; Gamborg's B-5 basal salt; chloramphenicol; 6-furfurylaminopurine; Sucrose; In ethanol; water; for 192h;

DOI:10.1016/j.tetasy.2006.07.029

upstream raw materials:

2-Methylcyclohexanone

ortho-cresol

(+/-)-cis-2-methylcyclohexanol acetate

Octanoic acid (1R,2S)-2-methyl-cyclohexyl ester

Downstream raw materials:

Diazo-acetic acid (1R,2S)-2-methyl-cyclohexyl ester

Diazo-acetic acid (1S,2S)-2-methyl-cyclohexyl ester

1-iodo-2-methylcyclohexane

2-methyl-1-phenylcyclohexanol

Refernces

• 1、 Beach,Ashby. "". . p. 906,907. Retrieved 1971.
• 2、 Garner, Charles M.,Jones, Andrew J.,Savage, Quentin R.,Wood, John L.,von Dollen, Breanna. "A crystalline, internally-coordinated chloroborane for asymmetric hydroboration". supporting information. . Retrieved 2022/02/01.
• 3、 Gheewala, Chirag D.,Hirschi, Jennifer S.,Lee, Wai-Hang,Paley, Daniel W.,Vetticatt, Mathew J.,Lambert, Tristan H.. "Asymmetric Induction via a Helically Chiral Anion: Enantioselective Pentacarboxycyclopentadiene Br?nsted Acid-Catalyzed Inverse-Electron-Demand Diels-Alder Cycloaddition of Oxocarbenium Ions". supporting information. p. 3523 - 3527. Retrieved 2018/03/21.