2-methyl-1-phenylcyclohexanol

Base Information

• Chemical Name: 2-methyl-1-phenylcyclohexanol
• CAS No.: 15036-22-3
• Molecular Formula: C13H18 O
• Molecular Weight: 190.285
• Mol file: 15036-22-3.mol

Synonyms:2-Methyl-1-phenylcyclohexanol;NSC 68530

Chemical Property of 2-methyl-1-phenylcyclohexanol

Chemical Property:

• Vapor Pressure: 0.000428mmHg at 25°C
• Boiling Point: 302.8°C at 760 mmHg
• Flash Point: 119.1°C
• Density: 1.022g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-1-phenylcyclohexanol

There total 7 articles about 2-methyl-1-phenylcyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

trans-2-methylcyclohexanol (15963-37-8) + 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane (5123-13-7) → 2-methyl-1-phenylcyclohexanol (15036-22-3,30689-79-3,30689-80-6,134005-85-9,134005-86-0)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium tert-butylate; chlorobenzene; cesium fluoride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; In toluene; at 80 ℃; for 6h; Inert atmosphere;

DOI:10.1039/c1cc10826c

Reference yield: 82.0%

bromobenzene (108-86-1,52753-63-6) + 2-Methylcyclohexanone (583-60-8) → 1-phenyl-2-methylcyclohexanol (15036-22-3)

Guidance literature:

bromobenzene; With iodine; magnesium; In diethyl ether; for 2h; Inert atmosphere; Reflux;

2-Methylcyclohexanone; In diethyl ether; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.1c01264

Reference yield: 54.0%

benzoic acid ethyl ester (93-89-0,99341-95-4) + 1,5-bis(bromomagnesio)hexane (101934-18-3) → 1-phenyl-2-methylcyclohexanol (15036-22-3)

Guidance literature:

In tetrahydrofuran;

DOI:10.1021/jo00361a048

upstream raw materials:

2-Methylcyclohexanone

bromobenzene

benzoic acid ethyl ester

1,5-bis(bromomagnesio)hexane

Downstream raw materials:

6-bromo-1-phenylheptan-1-one

6-methyl-5,6-dihydro-[1,1'-biphenyl]-3(4H)-one

2-phenylfluorene

1-[4-(2-methyl-cyclohexyl)-phenyl]-ethanone

Refernces

• 1、 Berini, Christophe,Navarro, Oscar. "Ni-catalysed, domino synthesis of tertiary alcohols from secondary alcohols". supporting information; experimental part. p. 1538 - 1540. Retrieved 2012/02/16.
• 2、 Canonne, P.,Bernatchez, M.. "Reaction of 1,4-Bis(bromomagnesio)pentane and 1,5-Bis(bromomagnesio)hexane with Carboxylic acid Esters. A Useful, Highly Stereoselective Annelation". . p. 2147 - 2148. Retrieved 2007/10/02.