Benzphetamine

Base Information

• Chemical Name: Benzphetamine
• CAS No.: 156-08-1
• Molecular Formula: C17H21 N
• Molecular Weight: 239.36
• Hs Code.: 2921499090
• European Community (EC) Number: 226-489-2
• UNII: 0M3S43XK27
• DSSTox Substance ID: DTXSID4022656
• Nikkaji Number: J215.740C
• Wikipedia: Benzphetamine
• Wikidata: Q3322838
• NCI Thesaurus Code: C61647
• RXCUI: 1422
• Pharos Ligand ID: 3YK65VB2S2CN
• Metabolomics Workbench ID: 43141
• ChEMBL ID: CHEMBL3545985
• Mol file: 156-08-1.mol

Synonyms:Benzfetamine;Benzphetamine;Didrex

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Chemical Property of Benzphetamine

Chemical Property:

• Vapor Pressure: 0.000129mmHg at 25°C
• Refractive Index: nD19 1.5515
• Boiling Point: 334.3°Cat760mmHg
• PKA: pKa 6.55 (Uncertain)
• Flash Point: 141.5°C
• PSA: 3.24000
• Density: 0.996g/cm³
• LogP: 3.74960
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 239.167399674
• Heavy Atom Count: 18
• Complexity: 214

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=CC=C1)N(C)CC2=CC=CC=C2
• Isomeric SMILES: C[C@@H](CC1=CC=CC=C1)N(C)CC2=CC=CC=C2
• Uses: Benzphetamine is an appetite suppressant; used to assay certain isozymes of cytochrome P-450.
• Therapeutic Function: Antiobesity

Technology Process of Benzphetamine

There total 23 articles about Benzphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl chloride (100-44-7) + S-methamphetamine hydrochloride (51-57-0,4298-16-2) → benzphetamine (156-08-1)

Guidance literature:

S-methamphetamine hydrochloride; With potassium carbonate; In water; at 25 ℃;

benzyl chloride; In water; at 75 ℃;

Reference yield: 98.8%

Methamphetamin (537-46-2) + benzyl chloride (100-44-7) → benzphetamine (156-08-1) + S-methamphetamine hydrochloride (51-57-0,4298-16-2)

Guidance literature:

at 100 - 145 ℃; for 3.38333h; Product distribution / selectivity;

Reference yield: 95.0%

Methamphetamin (537-46-2) + benzyl chloride (100-44-7) → benzphetamine (156-08-1) + benzfetamine hydrochloride (5411-22-3) + S-methamphetamine hydrochloride (51-57-0,4298-16-2)

Guidance literature:

In water; toluene; at 70 - 120 ℃; for 8.16667h; Product distribution / selectivity;

upstream raw materials:

benzfetamine hydrochloride

Methamphetamin

benzyl chloride

benzyl bromide

Downstream raw materials:

benzfetamine hydrochloride

N-Demethylbenzphetamine

Refernces

• 1、 -. "Preparation method of benzphetamine hydrochloride". . . Retrieved 2020/01/25.
• 2、 Lalwani, Komal G.,Sudalai, Arumugam. "A short enantioselective synthesis of ephedrine, amphetamine and their analogues via two stereocentered Co(III)-catalyzed hydrolytic kinetic resolution of racemic syn-benzyloxy epoxide". supporting information. p. 6488 - 6490. Retrieved 2015/11/16.