5411-22-3

Basic information

• Product Name: BENZPHETAMINE HYDROCHLORIDE--DEA
• Synonyms: d-benzphetaminehydrochloride;didrex;inapetyl;n,alpha-dimethyl-n-(phenylmethyl)-,hydrochloride,(s)-benzeneethanamin;n-benzyl-n,alpha-dimethyl-,hydrochloride,(+)-phenethylamin;nsc10937;BENZPHETAMINE HYDROCHLORIDE--DEA;benzphetamine hydrochloride--dea*schedule iii ite
• CAS NO: 5411-22-3
• Molecular Formula: C₁₇H₂₁N*ClH
• Molecular Weight: 275.821
• EINECS: 226-489-2
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 5411-22-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 129-130°
• Boiling Point: 334.3°Cat760mmHg
• Flash Point: 11 °C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.000129mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: BENZPHETAMINE HYDROCHLORIDE--DEA(CAS DataBase Reference)
• NIST Chemistry Reference: BENZPHETAMINE HYDROCHLORIDE--DEA(5411-22-3)
• EPA Substance Registry System: BENZPHETAMINE HYDROCHLORIDE--DEA(5411-22-3)

Safety Data

• Hazard Codes: T,F
• Statements: 23/24/25-63-39/23/24/25-11
• Safety Statements: 22-36/37/39-45-36/37-16
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: SG9625000
• Hazardous Substances Data: 5411-22-3(Hazardous Substances Data)

Usage

Description

BENZPHETAMINE HYDROCHLORIDE--DEA, also known as Benzphetamine, is a hydrochloride salt of a sympathomimetic agent with properties similar to dextroamphetamine. It is a controlled substance classified as a stimulant and anorexic, primarily used in the treatment of obesity.

Uses

Used in Pharmaceutical Industry:
BENZPHETAMINE HYDROCHLORIDE--DEA is used as an anorexic agent for the treatment of obesity. It helps in suppressing appetite and increasing the metabolic rate, which aids in weight loss.
Used in Research and Development:
BENZPHETAMINE HYDROCHLORIDE--DEA is used as a research compound for studying the effects of stimulants on the central nervous system and their potential applications in various medical conditions.
Brand Name:
The brand name for BENZPHETAMINE HYDROCHLORIDE--DEA is Didrex, which is manufactured by Pharmacia & Upjohn.

InChI:InChI=1/C17H21N.ClH/c1-15(13-16-9-5-3-6-10-16)18(2)14-17-11-7-4-8-12-17;/h3-12,15H,13-14H2,1-2H3;1H/t15-;/m0./s1

Upstream product

• 13906-90-6 2-benzylaziridine 
• 5267-64-1 (R)-2-amino-3-phenylpropanol 
• 673-06-3 D-(R)-phenylalanine 
• 537-46-2 Methamphetamin 
• 100-44-7 benzyl chloride 
• 156-08-1 benzphetamine 
• 1334921-74-2 C₁₅H₂₃NO₂ 
• 152614-95-4 BOC-pseudoephedrine 
• 345-78-8 Novafed 
• 51-57-0 S-methamphetamine hydrochloride 

Downstream Products

• 156-08-1 benzphetamine 

Relevant articles and documents

Benzphetamine hydrochloride preparation method

The invention relates to the field of chemical pharmacy, particularly to a benzphetamine hydrochloride preparation method. According to the invention, the method avoids the use of ephedrine, pseudoephedrine, deoxyephedrine and other management and control products, has characteristics of inexpensive and easily-available raw materials and synthesis cost reducing, can obtain the high-purity target compound at high yield, and is suitable for industrial large-scale production.

An efficient, scalable process for benzphetamine hydrochloride

Commercial manufacturing of benzphetamine hydrochloride along with its impurity profiling is disclosed. Deoxygenation of pseudoephedrine is reported with ～100% retention by shielding the amine group as its tert-butyl carbamate, which is very straightforward to eliminate at the end. Four unknown process-related impurities are isolated from the samples of final API and characterized on the basis of their NMR and mass spectral analysis. Structures of the isolated impurities are confirmed by independent syntheses and coinjecting with the isolated one.

HIGHLY PURE CRYSTALLINE BENZPHETAMINE HYDROCHLORIDE AND PROCESSES FOR PREPARING

A highly pure crystalline form of benzphetamine hydrochloride and methods for the purification and crystallization of benzphetamine hydrochloride in high yield are disclosed.