51-57-0 Usage
Description
(+)METHAMPHETAMINE HYDROCHLORIDE, also known as (+)-1-phenyl-2-methylaminopropane hydrochloride or Desoxyephedrine hydrochloride (Desoxyn), is the N-methyl analog of dextroamphetamine. It is a more physiologically active isomer of (±)-methamphetamine and is characterized by its off-white solid appearance. (+)METHAMPHETAMINE HYDROCHLORIDE has a higher central nervous system activity and lower peripheral action compared to dextroamphetamine. However, it is also known for its high abuse potential and is regulated as a Schedule II compound in the United States. Its medicinal uses are similar to those of dextroamphetamine.
Uses
Used in Pharmaceutical Industry:
(+)METHAMPHETAMINE HYDROCHLORIDE is used as a medicinal compound for [application reason] due to its central nervous system activity and similarity to dextroamphetamine. It is used in the treatment of attention deficit hyperactivity disorder (ADHD) and as a component in certain nasal decongestants.
Used in Research and Forensic Applications:
(+)METHAMPHETAMINE HYDROCHLORIDE is used as an analytical reference material for [application reason] in research and forensic applications. Its role in these fields is to provide a reference for the identification and analysis of the compound, which is crucial in understanding its effects and potential for abuse.
Used in Drug Enforcement and Policy:
(+)METHAMPHETAMINE HYDROCHLORIDE is used as a regulated substance for [application reason] in drug enforcement and policy. Its classification as a Schedule II compound in the United States indicates its high potential for abuse and the need for strict control over its production, distribution, and use.
Originator
Desoxyn ,Abbott Laboratories
Manufacturing Process
2 Methods of prepearing of methamphetamine: 1. (-)-Ephedrin was reduced by hydrogenesation with hydrogen in the presence of Pt-C catalyst to give the (+)-N-α-dimethylphenethylamine (methamphetamine), melting point 172°-174°C.2. Methamphetamine was obtained by the methylation of
phenylisopropylamine.
To give methamphetamine hydrochloride the base methamphetamine was
treated by eqimolar quantity of hydrochloric acid.
Therapeutic Function
Sympathomimetic, Central stimulant
Biochem/physiol Actions
Sympathomimetic with more potent central effects than amphetamine. It is transported into terminals via the monoamine transporters and induces release of dopamine, norepinephrine, epinephrine, and serotonin. Dopamine release is important for the addictive properties of methamphetamine while norepinephrine and epinephrine release are important for the cardiovascular effects. Serotonin neurotoxin.
Safety Profile
Poison by ingestion,
subcutaneous, intravenous, and
intraperitoneal routes. An experimental
teratogen. Experimental reproductive
effects. Questionable carcinogen with
experimental neoplastigenic data. When heated to decomposition it emits toxic
fumes of NOx and HCl. See also
BENZEDRINE and various amphetamines.
Check Digit Verification of cas no
The CAS Registry Mumber 51-57-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 1 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 51-57:
(4*5)+(3*1)+(2*5)+(1*7)=40
40 % 10 = 0
So 51-57-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H15N.ClH/c1-9(11-2)8-10-6-4-3-5-7-10;/h3-7,9,11H,8H2,1-2H3;1H/t9-;/m0./s1
51-57-0Relevant articles and documents
A short enantioselective synthesis of ephedrine, amphetamine and their analogues via two stereocentered Co(III)-catalyzed hydrolytic kinetic resolution of racemic syn-benzyloxy epoxide
Lalwani, Komal G.,Sudalai, Arumugam
, p. 6488 - 6490 (2015/11/16)
An efficient route for the synthesis of 6 drugs belonging to phenethylamine and amphetamine classes in excellent overall yields and high optical purity has been described. The strategy involves introduction of stereogenic centers by means of two-stereocentered Co(III)-catalyzed hydrolytic kinetic resolution (HKR) of racemic syn-benzyloxy epoxide followed by Pd-catalyzed regioselective cationic hydrogenation of amino alcohols as the key reactions.
Significant determinants of isotope composition during HI/Pred synthesis of methamphetamine
David, Gabrielle E.,Hibbert, D. Brynn,Frew, Russell D.,Hayman, Alan R.
experimental part, p. 22 - 29 (2010/06/12)
Methamphetamine HCl was synthesized using three variations of the hydriodic acid/red phosphorus (HI/Pred) synthetic route. A Plackett-Burman experimental design was used to determine how reaction parameters affected the isotopic composition of the product. Isotope ratio mass spectrometry results showed only the source of precursor 13C was significant in determining product δ13C; the manufacturer, reaction temperature, time, scale, and source of HI were not significant. The precursor was also the main determinant of product δ2H, with smaller contributions from the HI source for one method. From precursor to product, large δ2H depletion occurred for most samples. Deuterium nuclear magnetic resonance spectroscopy (2H NMR) was used to investigate the specific site of this. Significant fraction of deuterium was observed only at the benzylic position, the site of hydrogen addition during synthesis. Methamphetamine synthesized from ephedrine was shown to be depleted in this position.
PROCESS FOR PREPARING BENZYLATED AMINES
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Page/Page column 6-7, (2008/06/13)
This present invention relates to a process for preparing benzylated amines by the reaction of an amine selected from methamphetamine and propylhexedrine with benzyl halide. Numerous improvements are obtained by employing the amine in molar excess with respect to benzyl halide, preferably in a molar ratio of 2 to 1. The excess amine is employed to selectively neutralize by-product acid as the amine salt. The amine salt is then separated from the reaction mixture and basified to reclaim starting amine for recycle to the process.
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