4-NITROPHENYLGLYOXYLIC ACID

Base Information

• Chemical Name: 4-NITROPHENYLGLYOXYLIC ACID
• CAS No.: 14922-36-2
• Molecular Formula: C8H5 N O5
• Molecular Weight: 195.131
• Hs Code.: 2918300090
• Mol file: 14922-36-2.mol

Synonyms:Glyoxylicacid, (p-nitrophenyl)- (7CI,8CI); (4-Nitrophenyl)glyoxylic acid;(4-Nitrophenyl)oxoacetic acid; (p-Nitrophenyl)glyoxylic acid;4-Nitrobenzoylformic acid; p-Nitrobenzoylformic acid

Chemical Property of 4-NITROPHENYLGLYOXYLIC ACID

Chemical Property:

• Vapor Pressure: 1.67E-06mmHg at 25°C
• Melting Point: 113-115°C
• Boiling Point: 381.6°Cat760mmHg
• PKA: 1.72±0.54(Predicted)
• Flash Point: 173.1°C
• PSA: 100.19000
• Density: 1.531g/cm³
• LogP: 1.38530
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Nitrophenyl)-2-oxoacetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-NITROPHENYLGLYOXYLIC ACID

There total 11 articles about 4-NITROPHENYLGLYOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(4-nitrophenyl)ethanone (100-19-6) → 4-nitrophenylglyoxylic acid (14922-36-2)

Guidance literature:

With pyridine; selenium(IV) oxide; at 90 - 110 ℃;

DOI:10.1080/00397910802369554

Reference yield: 34.0%

4-ethylnitrobenzene (100-12-9,94234-68-1,34527-20-3) → 4-nitrophenylglyoxylic acid (14922-36-2)

Guidance literature:

With potassium permanganate;

DOI:10.1007/BF00772997

Reference yield:

4-nitro-benzoyl chloride (122-04-3) → 4-nitrophenylglyoxylic acid (14922-36-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / trans-benzyl(chloro)bis(triphenylphosphine)palladium(II) / benzene / 3 h / Heating

2: 1) pyridinium chlorochromate, 2) aq. NaOH / 1) CH₂Cl₂, reflux, 3 d, 2) Et₂O, 30 min

With sodium hydroxide; pyridinium chlorochromate; trans-benzyl(chloro)bis(triphenylphosphine)palladium(II); In benzene;

DOI:10.1055/s-1990-27005

upstream raw materials:

2-hydroxy-2-(4-nitrophenyl)acetic acid

4-ethylnitrobenzene

4-nitrobenzoyl cyanide

(5,6-Dihydro-[1,4]dioxin-2-yl)-(4-nitro-phenyl)-methanone

Downstream raw materials:

methyl p-nitrophenylglyoxylate

methyl 4-nitrobenzoylformate dimethylketal

3-(1-Methyl-1H-indol-3-yl)-4-(4-nitro-phenyl)-furan-2,5-dione

allyl 4-nitrophenylglyoxylate

Refernces

• 1、 Leont'eva, L. I.,Azizov, U. M.,Khadzhieva, U. A.,Zakirov, U. B.,Radzhapova, Sh. D.,Karshiev, D. N.. "ANTIINFLAMMATORY ACTIVITY OF DERIVATIVES OF PHENYLGLYOXYLIC ACID". . p. 195 - 197. Retrieved 1993.
• 2、 Laha, Joydev K.,Hunjan, Mandeep Kaur. "K2S2O8mediated synthesis of 5-Aryldipyrromethanes and meso-substituted A4-Tetraarylporphyrins". . p. 664 - 673. Retrieved 2021/06/03.
• 3、 Laha, Joydev K.,Kaur Hunjan, Mandeep,Hegde, Shalakha,Gupta, Anjali. "Aroylation of Electron-Rich Pyrroles under Minisci Reaction Conditions". supporting information. p. 1442 - 1447. Retrieved 2020/02/22.