2-(4-(N-(5-acetoxymethyl)phenyl-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-N-acetylsulfamoyl)phenyl)-2-methylpropyl acetate

Base Information

• Chemical Name: 2-(4-(N-(5-acetoxymethyl)phenyl-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-N-acetylsulfamoyl)phenyl)-2-methylpropyl acetate
• CAS No.: 374068-00-5
• Molecular Formula: C₃₃H₃₄BrN₅O₉S
• Molecular Weight: 756.631
• Mol file: 374068-00-5.mol

Synonyms:2-(4-(N-(5-acetoxymethyl)phenyl-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-N-acetylsulfamoyl)phenyl)-2-methylpropyl acetate

Chemical Property of 2-(4-(N-(5-acetoxymethyl)phenyl-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-N-acetylsulfamoyl)phenyl)-2-methylpropyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(N-(5-acetoxymethyl)phenyl-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-N-acetylsulfamoyl)phenyl)-2-methylpropyl acetate

There total 11 articles about 2-(4-(N-(5-acetoxymethyl)phenyl-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-N-acetylsulfamoyl)phenyl)-2-methylpropyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-methyl-2-phenylpropionate (2901-13-5) → 2-(4-(N-(5-acetoxymethyl)phenyl-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-N-acetylsulfamoyl)phenyl)-2-methylpropyl acetate (374068-00-5)

Guidance literature:

Multi-step reaction with 12 steps

1: ClSO₃H / CH₂Cl₂ / 22 h / 20 °C

2: 1.56 g / aq. NH₄OH / ethyl acetate / 2 h / 20 °C

3: 94 percent / aq. NaOH / methanol / 22 h / 20 °C

4: 98 percent / NaBH₄; BF₃*Et₂O / tetrahydrofuran / 3 h / 20 °C

5: 71 percent / K₂CO₃ / dimethylsulfoxide / 1.5 h / 80 °C

6: 83 percent / 10-camphorsulfonic acid / CH₂Cl₂ / 1.5 h / 20 °C

7: NaH / 48 h / 110 °C

8: 395 mg / NaH / N,N-dimethyl-acetamide; tetrahydrofuran / 3 h / 20 °C

9: 87 percent / p-TsOH*H₂O / methanol; tetrahydrofuran / 16 h / 20 °C

10: 88 percent / pyridine / 18 h / 20 °C

11: NBS; AIBN / CCl₄ / 2 h / Heating

12: 106 mg / NaI / dimethylformamide / 3 h / 60 °C

With pyridine; chlorosulfonic acid; ammonium hydroxide; sodium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; (1S)-10-camphorsulfonic acid; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; sodium iodide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl acetamide; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm000538f

Reference yield:

4-(2-hydroxy-1,1-dimethylethyl)benzenesulfonamide (374067-96-6) → 2-(4-(N-(5-acetoxymethyl)phenyl-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-N-acetylsulfamoyl)phenyl)-2-methylpropyl acetate (374068-00-5)

Guidance literature:

Multi-step reaction with 8 steps

1: 71 percent / K₂CO₃ / dimethylsulfoxide / 1.5 h / 80 °C

2: 83 percent / 10-camphorsulfonic acid / CH₂Cl₂ / 1.5 h / 20 °C

3: NaH / 48 h / 110 °C

4: 395 mg / NaH / N,N-dimethyl-acetamide; tetrahydrofuran / 3 h / 20 °C

5: 87 percent / p-TsOH*H₂O / methanol; tetrahydrofuran / 16 h / 20 °C

6: 88 percent / pyridine / 18 h / 20 °C

7: NBS; AIBN / CCl₄ / 2 h / Heating

8: 106 mg / NaI / dimethylformamide / 3 h / 60 °C

With pyridine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); (1S)-10-camphorsulfonic acid; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; sodium iodide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm000538f

Reference yield:

2-methyl-2-(4-sulfamoylphenyl)propionic acid (374067-95-5) → 2-(4-(N-(5-acetoxymethyl)phenyl-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-N-acetylsulfamoyl)phenyl)-2-methylpropyl acetate (374068-00-5)

Guidance literature:

Multi-step reaction with 9 steps

1: 98 percent / NaBH₄; BF₃*Et₂O / tetrahydrofuran / 3 h / 20 °C

2: 71 percent / K₂CO₃ / dimethylsulfoxide / 1.5 h / 80 °C

3: 83 percent / 10-camphorsulfonic acid / CH₂Cl₂ / 1.5 h / 20 °C

4: NaH / 48 h / 110 °C

5: 395 mg / NaH / N,N-dimethyl-acetamide; tetrahydrofuran / 3 h / 20 °C

6: 87 percent / p-TsOH*H₂O / methanol; tetrahydrofuran / 16 h / 20 °C

7: 88 percent / pyridine / 18 h / 20 °C

8: NBS; AIBN / CCl₄ / 2 h / Heating

9: 106 mg / NaI / dimethylformamide / 3 h / 60 °C

With pyridine; sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; (1S)-10-camphorsulfonic acid; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; sodium iodide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm000538f

upstream raw materials:

ethyl 2-methyl-2-phenylpropionate

4-(2-hydroxy-1,1-dimethylethyl)benzenesulfonamide

2-methyl-2-(4-sulfamoylphenyl)propionic acid

ethyl 2-methyl-2-(4-sulfamoylphenyl)propionate

Refernces