1-Methylquinolinium chloride

Base Information

• Chemical Name: 1-Methylquinolinium chloride
• CAS No.: 2525-21-5
• Molecular Formula: C10H10 N . Cl
• Molecular Weight: 179.649
• DSSTox Substance ID: DTXSID80883858
• Mol file: 2525-21-5.mol

Synonyms:1-methylquinolinium;1-methylquinolinium bromide;1-methylquinolinium chloride;1-methylquinolinium hydroxide;1-methylquinolinium iodide;1-methylquinolinium mesylate;1-methylquinolinium monopicrate;1-methylquinolinium pentaiodide;1-methylquinolinium perchlorate;1-methylquinolinium tetrafluoroborate (1-);1-methylquinolinium triiodide

Chemical Property of 1-Methylquinolinium chloride

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: g/cm³
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 179.0501770
• Heavy Atom Count: 12
• Complexity: 133

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[N+]1=CC=CC2=CC=CC=C21.[Cl-]

Technology Process of 1-Methylquinolinium chloride

There total 6 articles about 1-Methylquinolinium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.2%

1-methyl-2-trichloromethyl-1,2-dihydroquinoline (132363-86-1) → 1-methyl-2-quinolin-2(1H)-one (606-43-9) + N-methylquinoline hydrochloride (2525-21-5)

Guidance literature:

With potassium hydroxide; In methanol; for 2h; Heating;

DOI:10.1248/cpb.38.2577

Reference yield: 6.0%

1-methyl-2-trichloromethyl-1,2-dihydroquinoline (132363-86-1) → N-methylquinoline hydrochloride (2525-21-5) + 1-methyl-2-trichloromethyl-1,2,3,4-tetrahydroquinoline (132363-89-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 20h; Ambient temperature;

DOI:10.1248/cpb.38.2577

Reference yield:

N-methylquinolinium iodide (3947-76-0) → N-methylquinoline hydrochloride (2525-21-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / KOH / methanol / Ambient temperature

2: 54.2 percent / 0.1 N KOH / methanol / 2 h / Heating

With potassium hydroxide; In methanol;

DOI:10.1248/cpb.38.2577

upstream raw materials:

N-benzoylisoquinolinium chloride

2-(indol-3-yl)-1-methyl-1,2-dihydroquinoline

1-methyl-2-trichloromethyl-1,2-dihydroquinoline

N-Benzoylquinolinium chloride

Downstream raw materials:

1,2-dihydro-2-imino-1-methylquinoline

1-methyl-2-quinolin-2(1H)-one

1-methyl-4-quinolone

Refernces

• 1、 Sheinkman A. K.,Chmilenko T. S.,Nezdiiminoga T. N.. "THE DUAL REACTIVITY OF 1,2-DISUBSTITUED DIHYDRO-N-HETEROAROMATIC SYSTEMS. 5. A CASE OF AN UNUSUALLY EASY HETEROLYSIS OF THE INTERNUCLEAR BOND IN 2-(INDOL-3-YL)-1-METHYL-1,2-DIHYDROQUINOLINE AND ITS ANALOGS.". . p. 991 - 996. Retrieved 2007/10/02.