Technology Process of ethyl (3aS,4Z,6aR)-5-[1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-5-ylidene]-pentanoate
There total 12 articles about ethyl (3aS,4Z,6aR)-5-[1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-5-ylidene]-pentanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethyl 5-iodopentanoate;
With
chloro-trimethyl-silane; bromine; zinc;
In
tetrahydrofuran; toluene;
at 50 - 60 ℃;
for 1h;
(3aS,6aR)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione;
With
N,N-dimethyl-formamide;
palladium on activated charcoal;
In
tetrahydrofuran; toluene;
at 25 - 30 ℃;
for 18h;
Further stages.;
DOI:10.1002/adsc.200600610
- Guidance literature:
-
(5-ethoxy-5-oxopentyl)zinc(II) iodide; (3aS,6aR)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione;
With
palladium on activated charcoal;
In
toluene;
at 30 ℃;
for 15h;
With
hydrogenchloride;
In
N,N-dimethyl-formamide; toluene;
at 25 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: PdCl2(PPh3)2 / tetrahydrofuran; toluene; dimethylformamide / 35 h / 20 °C
2: 1.16 g / p-TsOH*H2O / toluene / 18 h / 20 °C
With
toluene-4-sulfonic acid;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
1: Alkylation / 2: Dehydration;
DOI:10.1016/S0040-4039(00)00781-4