Technology Process of L-tartaric acid (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
There total 8 articles about L-tartaric acid (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
methanol;
at 0 - 65 ℃;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dmap / acetonitrile / 25 - 30 °C
1.2: 30 - 50 °C
2.1: ammonium hydroxide; ammonium acetate; acetic acid / water; methanol / 6 h / 60 - 65 °C
3.1: dimethylsulfide borane complex; methanesulfonic acid / isopropyl alcohol; tetrahydrofuran / 4 h / -10 - -5 °C
4.1: methanol / 3 h / 60 - 65 °C
With
ammonium hydroxide; methanesulfonic acid; dimethylsulfide borane complex; ammonium acetate; acetic acid;
dmap;
In
tetrahydrofuran; methanol; water; isopropyl alcohol; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dmap / acetonitrile / 25 - 30 °C
1.2: 30 - 50 °C
2.1: ammonium hydroxide; ammonium acetate; acetic acid / water; methanol / 6 h / 60 - 65 °C
3.1: dimethylsulfide borane complex; methanesulfonic acid / isopropyl alcohol; tetrahydrofuran / 4 h / -10 - -5 °C
4.1: methanol / 3 h / 60 - 65 °C
With
ammonium hydroxide; methanesulfonic acid; dimethylsulfide borane complex; ammonium acetate; acetic acid;
dmap;
In
tetrahydrofuran; methanol; water; isopropyl alcohol; acetonitrile;