Januvia

Base Information Edit

Chemical Name:Januvia
CAS No.:654671-78-0
Deprecated CAS:790712-60-6
Molecular Formula:C16H18F6N5O5P
Molecular Weight:505.31
Hs Code.:2933990090
European Community (EC) Number:871-227-8
UNII:494P4635I6
DSSTox Substance ID:DTXSID10215789
Wikidata:Q27259224
NCI Thesaurus Code:C73811
RXCUI:621590
Pharos Ligand ID:1CS459QWD6NB
ChEMBL ID:CHEMBL393336
Mol file:654671-78-0.mol

Synonyms:0431, MK;4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine;Anhydrous, Sitagliptin Phosphate;Januvia;MK 0431;MK-0431;MK0431;Monohydrate, Sitagliptin Monophosphate;Monohydrate, Sitagliptin Phosphate;Monophosphate Monohydrate, Sitagliptin;Phosphate Anhydrous, Sitagliptin;Phosphate Monohydrate, Sitagliptin;Phosphate, Sitagliptin;sitagliptin;sitagliptin monophosphate monohydrate;sitagliptin phosphate;sitagliptin phosphate anhydrous;sitagliptin phosphate monohydrate

Suppliers and Price of Januvia

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Sitagliptin Phosphate
50mg
$ 55.00

Tocris
Sitagliptin Phosphate ≥98%(HPLC)
10
$ 93.00

Tocris
Sitagliptin Phosphate ≥98%(HPLC)
50
$ 390.00

Sigma-Aldrich
Sitagliptin phosphate United States Pharmacopeia (USP) Reference Standard
200 mg
$ 353.00

Sigma-Aldrich
Sitagliptin Phosphate Pharmaceutical Secondary Standard; Certified Reference Material
1 g
$ 129.00

Medical Isotopes, Inc.
Sitagliptin Phosphate
1 g
$ 490.00

Crysdot
Sitagliptin Phosphate 98+%
1g
$ 196.00

ChemScene
Sitagliptin Phosphate
200mg
$ 72.00

ChemScene
Sitagliptin Phosphate
100mg
$ 60.00

Cayman Chemical
Sitagliptin (phosphate) ≥98%
50mg
$ 32.00

Total 185 raw suppliers

Chemical Property of Januvia Edit

Chemical Property:

Appearance/Colour:white solid
Vapor Pressure:2.59E-11mmHg at 25°C
Melting Point:202-204 °C
Boiling Point:529.9 °C at 760 mmHg
Flash Point:274.3 °C
PSA：164.61000
LogP:1.72610
Storage Temp.:-20°C Freezer
Solubility.:Methanol (Slightly, Heated), Water (Sparingly, Sonicated)
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:4
Exact Mass:505.09497466
Heavy Atom Count:33
Complexity:616

Purity/Quality:

98%, ^*data from raw suppliers

Sitagliptin Phosphate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)CC(CC3=CC(=C(C=C3F)F)F)N.OP(=O)(O)O
Isomeric SMILES:C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.OP(=O)(O)O
Recent ClinicalTrials:Study of Sitagliptin Treatment in Patients With Type 2 Diabetes During Ramadan (0431-263)
Recent EU Clinical Trials:PIONEER 12 China multi-regional clinical trial: Efficacy and safety of oral semaglutide versus sitagliptin in subjects with type 2 diabetes mellitus treated with metformin
Description Sitagliptin is the first novel dipeptidyl peptidase IV inhibitor from Merck for the treatment of type 2 diabetes without weight gain and the incidence of hypoglycemia was similar to placebo. Sitagliptin acts by enhancing the body’s incretin system, which helps to regulate glucose by affecting β and α cells in the pancreas.
Uses A trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes. Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.

Technology Process of Januvia

There total 171 articles about Januvia which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: (3R)-3-[[(1R)-1-phenylethyl]amino]-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one phosphate

: 654671-78-0,790712-60-6
sitagliptin phosphate

Guidance literature:: (3R)-3-[[(1R)-1-phenylethyl]amino]-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one phosphate; With hydrogen; acetic acid; at 60 ℃; for 8h; Autoclave; Large scale;

In water; isopropyl alcohol; at 20 - 75 ℃; for 4h; Reagent/catalyst; Autoclave; Large scale;