Technology Process of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine adipic acid
There total 2 articles about (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine adipic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
isopropyl alcohol;
at 25 - 50 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium chloride; sodium hydrogencarbonate / water; ethyl acetate / 25 - 42 °C
2: ethanol / 25 - 80 °C
With
sodium hydrogencarbonate; sodium chloride;
In
ethanol; water; ethyl acetate;
