4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphoxide

Base Information

• Chemical Name: 4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphoxide
• CAS No.: 154521-75-2
• Molecular Formula: C₁₄H₆Cl₂F₆OS
• Molecular Weight: 407.163
• Mol file: 154521-75-2.mol

Synonyms:4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphoxide

Chemical Property of 4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphoxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphoxide

There total 1 articles about 4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-4-chloro-2-(trifluoromethyl)benzene (344-65-0) → 4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphoxide (154521-75-2)

Guidance literature:

With thionyl chloride; magnesium; Yield given. Multistep reaction; 1.) Et₂O, 2 h, 2.) Et₂O, 0 deg C, 19 h; reflux, 0.5 h;

DOI:10.1016/0022-1139(94)03080-4

Reference yield: 59.0%

4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphoxide (154521-75-2) → 4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphone (154521-76-3)

Guidance literature:

With chromium(VI) oxide; In acetic acid; at 100 ℃; for 24h;

DOI:10.1016/0022-1139(94)03080-4

Reference yield: 47.0%

4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphoxide (154521-75-2) → 4-chloro-4'-hydroxy-2,2'-bis(trifluoromethyl)diphenyl sulphoxide

Guidance literature:

With potassium hydroxide; In water; dimethyl sulfoxide; at 130 ℃; for 1.5h;

DOI:10.1016/0022-1139(94)03080-4

upstream raw materials:

1-bromo-4-chloro-2-(trifluoromethyl)benzene

Downstream raw materials:

4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphone

Refernces