4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphone

Base Information

• Chemical Name: 4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphone
• CAS No.: 154521-76-3
• Molecular Formula: C₁₄H₆Cl₂F₆O₂S
• Molecular Weight: 423.163
• Mol file: 154521-76-3.mol

Synonyms:4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphone

Chemical Property of 4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphone

There total 2 articles about 4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphoxide (154521-75-2) → 4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphone (154521-76-3)

Guidance literature:

With chromium(VI) oxide; In acetic acid; at 100 ℃; for 24h;

DOI:10.1016/0022-1139(94)03080-4

Reference yield:

1-bromo-4-chloro-2-(trifluoromethyl)benzene (344-65-0) → 4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphone (154521-76-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mg, 2.) SOCl₂ / 1.) Et₂O, 2 h, 2.) Et₂O, 0 deg C, 19 h; reflux, 0.5 h

2: 59 percent / CrO₃ / acetic acid / 24 h / 100 °C

With chromium(VI) oxide; thionyl chloride; magnesium; In acetic acid;

DOI:10.1016/0022-1139(94)03080-4

Reference yield: 40.0%

4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphone (154521-76-3) → 4-chloro-4'-hydroxy-2,2'-bis(trifluoromethyl)diphenyl sulphone

Guidance literature:

With potassium hydroxide; In water; dimethyl sulfoxide; at 120 ℃; for 5h;

DOI:10.1016/0022-1139(94)03080-4

upstream raw materials:

4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphoxide

1-bromo-4-chloro-2-(trifluoromethyl)benzene

Refernces