N-(2,5-Dimethylphenyl)acetamide

Base Information

• Chemical Name: N-(2,5-Dimethylphenyl)acetamide
• CAS No.: 2050-44-4
• Molecular Formula: C10H13 N O
• Molecular Weight: 163.219
• Hs Code.: 2924299090
• NSC Number: 43199,7646
• DSSTox Substance ID: DTXSID50174487
• Nikkaji Number: J55.069H
• ChEMBL ID: CHEMBL3728148
• Mol file: 2050-44-4.mol

Synonyms:N-(2,5-Dimethylphenyl)acetamide;2050-44-4;2,5-Dimethylacetanilide;2',5'-ACETOXYLIDIDE;Acetamide, N-(2,5-dimethylphenyl)-;Acetanilide, 2',5'-dimethyl-;NSC 7646;N-(2,5-Dimethyl-phenyl)-acetamide;NSC 43199;2',5'-Dimethylacetanilide;MFCD00220610;Acetamide, N-(2,5-dimethylphenyl)- (9CI);Acetanilide,5'-dimethyl-;Acetamide,5-dimethylphenyl)-;WLN: 1VMR B1 E1;N-Acetyl-2,5-xylidine;SCHEMBL90967;CHEMBL3728148;SCHEMBL17751173;DTXSID50174487;NSC7646;HMS1680H09;CAA05044;NSC-7646;NSC43199;N-(2,5-Dimethylphenyl)acetamide #;NSC-43199;AKOS000649588;AM82902;SY036049;CS-0281034;FT-0610164;7P-092;EN300-213005

Chemical Property of N-(2,5-Dimethylphenyl)acetamide

Chemical Property:

• Vapor Pressure: 0.00179mmHg at 25°C
• Melting Point: 129-132 °C(lit.)
• Boiling Point: 292.8°Cat760mmHg
• Flash Point: 169.7°C
• PSA: 29.10000
• Density: 1.052g/cm³
• LogP: 2.33480
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 163.099714038
• Heavy Atom Count: 12
• Complexity: 167

Purity/Quality:

98%min ^*data from raw suppliers

2′,4′-Dimethylacetanilide 98% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)C)NC(=O)C

Technology Process of N-(2,5-Dimethylphenyl)acetamide

There total 14 articles about N-(2,5-Dimethylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,5-Dimethylaniline (95-78-3) → N-(2,5-dimethylphenyl)acetamide (2050-44-4)

Guidance literature:

With acetic anhydride; In tetrahydrofuran; methanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield: 97.0%

2,5-Dimethylaniline (95-78-3) + acetic acid (64-19-7,77671-22-8) → N-(2,5-dimethylphenyl)acetamide (2050-44-4)

Guidance literature:

at 150 ℃; microwave irradiation;

DOI:10.1080/00397910701860372

Reference yield: 97.0%

para-xylene (106-42-3) + acetonitrile (75-05-8,26809-02-9) → N-(2,5-dimethylphenyl)acetamide (2050-44-4)

Guidance literature:

With potassium chloride; water; platinum; at 20 ℃; for 3h; Electrolysis;

upstream raw materials:

2,5-Dimethylaniline

acetic anhydride

acetic acid

3,6-dimethylcyclohex-2-enone

Downstream raw materials:

acetic acid-(2,4-dichloro-3,6-dimethyl-anilide)

acetic acid-(2,4,5-trichloro-3,6-dimethyl-anilide)

N-(2,5-Dimethyl-phenyl)-N-((E)-octa-2,7-dienyl)-acetamide

N-(2,5-dimethyl-4-nitrophenyl)acetamide

Refernces

• 1、 -. "NOVEL AGROCHEMICAL COMPOSITION COMPRISING 4-SUBSTITUTED PHENYLAMIDINE COMPOUNDS". Page/Page column 67. . Retrieved 2021/05/21.
• 2、 Kalla, Reddi Mohan Naidu,Reddy, Sirigireddy Sudharsan,Kim, Il. "Acylation of Phenols, Alcohols, Thiols, Amines and Aldehydes Using Sulfonic Acid Functionalized Hyper-Cross-Linked Poly(2-naphthol) as a Solid Acid Catalyst". . p. 2696 - 2705. Retrieved 2019/05/28.