2,5-DIMETHYL-4-NITRO ACETANILIDE

Base Information

• Chemical Name: 2,5-DIMETHYL-4-NITRO ACETANILIDE
• CAS No.: 6954-69-4
• Molecular Formula: C10H12N2O3
• Molecular Weight: 208.217
• Hs Code.: 2924299090
• Mol file: 6954-69-4.mol

Synonyms:2',5'-Acetoxylidide,4'-nitro- (6CI);NSC 67711;N-(2,5-dimethyl-4-nitrophenyl)acetamide;Acetamide, N-(2,5-dimethyl-4-nitrophenyl)-;

Chemical Property of 2,5-DIMETHYL-4-NITRO ACETANILIDE

Chemical Property:

• Vapor Pressure: 5.15E-06mmHg at 25°C
• Melting Point: 171-171.5℃ (benzene chloroform )
• Refractive Index: 1.595
• Boiling Point: 381.2 °C at 760 mmHg
• Flash Point: 184.4 °C
• PSA: 74.92000
• Density: 1.247 g/cm³
• LogP: 2.76620
• Storage Temp.: 2-8°C

Purity/Quality:

99.3% ^*data from raw suppliers

N-(2,5-Dimethyl-4-nitrophenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-DIMETHYL-4-NITRO ACETANILIDE

There total 8 articles about 2,5-DIMETHYL-4-NITRO ACETANILIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-(2,5-dimethylphenyl)acetamide (2050-44-4) → N-(2,5-dimethyl-4-nitrophenyl)acetamide (6954-69-4)

Guidance literature:

With sulfuric acid; nitric acid; at 0 ℃; for 0.75h;

Reference yield: 76.0%

4-nitro-2,5-xylidine (3460-29-5) + acetyl chloride (75-36-5) → N-(2,5-dimethyl-4-nitrophenyl)acetamide (6954-69-4)

Guidance literature:

With sodium carbonate; In acetone; for 18h; Reflux;

DOI:10.1021/ic502487x

Reference yield:

N-(2,5-dimethylphenyl)acetamide (2050-44-4) → N-(2,5-dimethyl-4-nitrophenyl)acetamide (6954-69-4) + acetic acid-(3,6-dimethyl-2-nitro-anilide) (35182-75-3)

Guidance literature:

With sulfuric acid; nitric acid; acetic acid;

DOI:10.1021/ja01166a074

upstream raw materials:

N-(2,5-dimethylphenyl)acetamide

nitric acid

2,5-Dimethylaniline

acetyl chloride

Downstream raw materials:

2,2′,5,5′-tetramethyl-4,4′-azodiacetanilide

2,5-dimethyl-4-aminoacetanilide

1-bromo-2,5-dimethyl-4-nitrobenzene

6-methyl-1H-indazole-5-amine

Refernces

• 1、 Choudhuri, Mohommad M. R.,Behzad, Mahdi,Al-Noaimi, Mousa,Yap, Glenn P. A.,Kaim, Wolfgang,Sarkar, Biprajit,Crutchley, Robert J.. "Variable noninnocence of substituted azobis(phenylcyanamido)diruthenium complexes". supporting information. p. 1508 - 1517. Retrieved 2015/06/16.
• 2、 -. "Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents". Page column 114. . Retrieved 2010/02/05.