Iodoform

Base Information

• Chemical Name: Iodoform
• CAS No.: 75-47-8
• Molecular Formula: CHI3
• Molecular Weight: 393.732
• Hs Code.: Oral rat LD50: 355 mg/kg
• European Community (EC) Number: 200-874-5,685-642-5
• NSC Number: 26251
• UNII: KXI2J76489
• DSSTox Substance ID: DTXSID4020743
• Nikkaji Number: J1.456G
• Wikipedia: Iodoform
• Wikidata: Q412393
• NCI Thesaurus Code: C77050
• Metabolomics Workbench ID: 52204
• ChEMBL ID: CHEMBL1451116
• Mol file: 75-47-8.mol

Synonyms:iodoform;tri-iodomethane

Chemical Property of Iodoform

Chemical Property:

• Appearance/Colour: yellow solid with a characteristic pungent and
• Vapor Pressure: 0.0339mmHg at 25°C
• Melting Point: 119-122 °C
• Refractive Index: 1.85
• Boiling Point: 250.668 °C at 760 mmHg
• Flash Point: 128.988 °C
• PSA: 0.00000
• Density: 3.864g/cm³
• LogP: 2.57500
• Storage Temp.: -20°C
• Sensitive.: Light Sensitive
• Solubility.: chloroform: soluble5%
• Water Solubility.: Insoluble.
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 393.7212
• Heavy Atom Count: 4
• Complexity: 8

Purity/Quality:

98% ^*data from raw suppliers

CHIT1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37-36/37/39-22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Uses -> Pharmaceuticals
• Canonical SMILES: C(I)(I)I
• Recent ClinicalTrials: Examination of the Prevention and Treatment Modalities of Alveolitis in Relation With Impacted Teeth Surgery
• Description: Iodoform is a stable, pale yellow crystalline solid. It is volatile with a characteristic pungent, unpleasant and penetrating odour, but with a sweetish taste. It is incompatible with strong oxidising agents, reducing agents, lithium, and metallic salts such as mercuric oxide, silver nitrate, strong bases, calomel, and tannin. Reports indicate that earlier iodoform was in use as a disinfectant and as an antiseptic or dressing and healing of wounds and sores for pets. Iodoform is the active ingredient in many antiseptic or dressing powders used for dogs and cats to prevent infection.
• Uses: Iodoform has limited use as a chemical intermediate and for medicinal purposes as disinfectant and antiseptic and has been used in veterinary medicine. Triiodomethane is a crystalline compound commonly used as a disinfectant. It can be used in the process of removing heavy metals such as mercury from fuids. It is used as a topical anti-infective, applied to the skin.

Technology Process of Iodoform

There total 165 articles about Iodoform which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-butylamine (109-73-9,85404-21-3) + acetophenone (98-86-2) → iodoform (75-47-8) + N-butylbenzamide (2782-40-3)

Guidance literature:

With tert.-butylhydroperoxide; iodine; In water; Petroleum ether; at 0 ℃; for 12h; Reagent/catalyst; Solvent;

DOI:10.1016/j.tet.2014.11.003

Reference yield:

methanol (67-56-1) + 1-(4-methoxyphenyl)ethanone (100-06-1) → iodoform (75-47-8) + 4-methoxybenzoic acid (100-09-4)

Guidance literature:

Reference yield:

carbon tetraiodide (507-25-5) → iodoform (75-47-8) + hydrogen iodide (10034-85-2)

Guidance literature:

at 140 ℃;

upstream raw materials:

4-methyl-pent-3-en-2-one

ethanol

carbon tetraiodide

chloroform

Downstream raw materials:

diiodomethane

trimethyl-phenyl-arsonium; compound of iodide with iodoform

Tributyl orthoformate

1,1-Diiod-2-phenylcyclopropan

Refernces

• 1、 Watt, G. W.,McBride, W. R.,Sowards, D. M.. "". . p. 1562 - 1564. Retrieved 1956.
• 2、 Langlykke,Peterson. "". . p. 163. Retrieved 1937.
• 3、 Bichsel, Yves,Von Gunten, Urs. "Formation of iodo-trihalomethanes during disinfection and oxidation of iodide-containing waters". . p. 2784 - 2791. Retrieved 2000.
• 4、 Kunz, R.. "". . p. 302 - 303. Retrieved 1920.
• 5、 Zhu, Chunyin,Wei, Wei,Du, Peng,Wan, Xiaobing. "Metal free amide synthesis via carbon-carbon bond cleavage". . p. 9615 - 9620. Retrieved 2015/01/09.