2-bromo-1-(2-bromoethyl)-4-chlorobenzene

Base Information

• Chemical Name: 2-bromo-1-(2-bromoethyl)-4-chlorobenzene
• CAS No.: 52927-98-7
• Molecular Formula: C₈H₇Br₂Cl
• Molecular Weight: 298.405
• Mol file: 52927-98-7.mol

Synonyms:2-bromo-1-(2-bromoethyl)-4-chlorobenzene

Chemical Property of 2-bromo-1-(2-bromoethyl)-4-chlorobenzene

Chemical Property:

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromo-1-(2-bromoethyl)-4-chlorobenzene

There total 6 articles about 2-bromo-1-(2-bromoethyl)-4-chlorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-(2-bromo-4-chlorophenyl)ethan-1-ol (52864-57-0) → 2-bromo-1-(2-bromoethyl)-4-chlorobenzene (52927-98-7)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

2-(2-bromo-4-chlorophenyl)acetic acid (52864-56-9) → 2-bromo-1-(2-bromoethyl)-4-chlorobenzene (52927-98-7)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether / Heating

2: PBr₃

With lithium aluminium tetrahydride; phosphorus tribromide; In diethyl ether;

DOI:10.1002/jhet.5570110312

Reference yield:

2-bromo-4-chlorobenzyl bromide (33924-45-7) → 2-bromo-1-(2-bromoethyl)-4-chlorobenzene (52927-98-7)

Guidance literature:

Multi-step reaction with 5 steps

1: aq. ethanol

2: H₂SO₄

3: aq. KOH / ethanol / Heating

4: LiAlH₄ / diethyl ether / Heating

5: PBr₃

With potassium hydroxide; lithium aluminium tetrahydride; sulfuric acid; phosphorus tribromide; In diethyl ether; ethanol;

DOI:10.1002/jhet.5570110312

upstream raw materials:

2-(2-bromo-4-chlorophenyl)ethan-1-ol

2-bromo-4-chlorobenzyl bromide

2-(2-bromo-4-chlorophenyl)acetic acid

2-(2-bromo-4-chlorophenyl)acetonitrile

Refernces

• 1、 Petigara,Yale. "Novel polycyclic heterocycles. XI. Synthesis of 11,12 dihydropyrido [2,1 b] [1,3] benzodiazepines, 6h pyrido[1,2 c] [1,3,5] benzoxadiazepines, and 6h pyrido[1,2 c] [1,3,5]benzothiadiazepines (1)". . p. 331 - 337. Retrieved 2007/10/04.