<1-methyl-2-(3-phenyl)ethyl>phosphoramidate de diethyle

Base Information

• Chemical Name: <1-methyl-2-(3-phenyl)ethyl>phosphoramidate de diethyle
• CAS No.: 154140-26-8
• Molecular Formula: C₁₄H₂₁F₃NO₃P
• Molecular Weight: 339.295
• Mol file: 154140-26-8.mol

Synonyms:<1-methyl-2-(3-phenyl)ethyl>phosphoramidate de diethyle

Chemical Property of <1-methyl-2-(3-phenyl)ethyl>phosphoramidate de diethyle

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <1-methyl-2-(3-phenyl)ethyl>phosphoramidate de diethyle

There total 2 articles about <1-methyl-2-(3-phenyl)ethyl>phosphoramidate de diethyle which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

norfenfluramine (1886-26-6) + diethyl chlorophosphate (814-49-3) → <1-methyl-2-(3-phenyl)ethyl>phosphoramidate de diethyle (154140-26-8)

Guidance literature:

With triethylamine; In dichloromethane; for 24h; Ambient temperature;

Reference yield:

rac-2-azido-1-<3-(trifluoromethyl)phenyl>propane + triethyl phosphite (122-52-1) → <1-methyl-2-(3-phenyl)ethyl>phosphoramidate de diethyle (154140-26-8)

Guidance literature:

Multistep reaction; 1.) ether, 26-29 degC, 40 h; 2.) 100 degC, 2 h;

Reference yield:

diethyl sulfate (64-67-5) + <1-methyl-2-(3-phenyl)ethyl>phosphoramidate de diethyle (154140-26-8) → Fenfluramine (458-24-2,3239-44-9,5220-89-3,37577-24-5)

Guidance literature:

With hydrogen bromide; sodium hydride; Yield given. Multistep reaction; 1.) DMF, 24 degC, overnight; 2.) room t., overnight;

upstream raw materials:

norfenfluramine

diethyl chlorophosphate

triethyl phosphite

Downstream raw materials:

Fenfluramine

Refernces