4-Benzoyl-benzoic acid (2E,6E,10E)-12-(tert-butyl-dimethyl-silanyloxy)-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

Base Information

• Chemical Name: 4-Benzoyl-benzoic acid (2E,6E,10E)-12-(tert-butyl-dimethyl-silanyloxy)-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester
• CAS No.: 618405-68-8
• Molecular Formula: C₃₅H₄₈O₄Si
• Molecular Weight: 560.849
• Mol file: 618405-68-8.mol

Synonyms:4-Benzoyl-benzoic acid (2E,6E,10E)-12-(tert-butyl-dimethyl-silanyloxy)-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

Chemical Property of 4-Benzoyl-benzoic acid (2E,6E,10E)-12-(tert-butyl-dimethyl-silanyloxy)-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Benzoyl-benzoic acid (2E,6E,10E)-12-(tert-butyl-dimethyl-silanyloxy)-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

There total 4 articles about 4-Benzoyl-benzoic acid (2E,6E,10E)-12-(tert-butyl-dimethyl-silanyloxy)-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-carboxybenzophenone (611-95-0) + (2E,6E,10E)-12-((tert-butyldimethylsilyl)oxy)-2,6,10-trimethyldodeca-2,6,10-trien-1-ol (412347-62-7) → 4-Benzoyl-benzoic acid (2E,6E,10E)-12-(tert-butyl-dimethyl-silanyloxy)-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester (618405-68-8)

Guidance literature:

With dmap; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1021/ja036178d

Reference yield:

Farnesol (106-28-5) → 4-Benzoyl-benzoic acid (2E,6E,10E)-12-(tert-butyl-dimethyl-silanyloxy)-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester (618405-68-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 99 percent / i-Pr₂NEt / CH₂Cl₂ / 20 °C

2.1: SeO₂; t-BuOOH; salycylic acid / CH₂Cl₂; H₂O; various solvent(s) / 12 h

2.2: 55 percent / NaBH₄ / methanol

3.1: 99 percent / DMAP; diisopropylcarbodiimide / CH₂Cl₂ / 20 °C

With tert.-butylhydroperoxide; dmap; selenium(IV) oxide; N-ethyl-N,N-diisopropylamine; salicylic acid; diisopropyl-carbodiimide; In dichloromethane; water; 3.1: Steglich reaction;

DOI:10.1021/ja036178d

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 4-Benzoyl-benzoic acid (2E,6E,10E)-12-(tert-butyl-dimethyl-silanyloxy)-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester (618405-68-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 99 percent / i-Pr₂NEt / CH₂Cl₂ / 20 °C

2.1: SeO₂; t-BuOOH; salycylic acid / CH₂Cl₂; H₂O; various solvent(s) / 12 h

2.2: 55 percent / NaBH₄ / methanol

3.1: 99 percent / DMAP; diisopropylcarbodiimide / CH₂Cl₂ / 20 °C

With tert.-butylhydroperoxide; dmap; selenium(IV) oxide; N-ethyl-N,N-diisopropylamine; salicylic acid; diisopropyl-carbodiimide; In dichloromethane; water; 3.1: Steglich reaction;

DOI:10.1021/ja036178d

upstream raw materials:

4-carboxybenzophenone

(2E,6E,10E)-12-((tert-butyldimethylsilyl)oxy)-2,6,10-trimethyldodeca-2,6,10-trien-1-ol

Farnesol

tert-butyldimethylsilyl chloride

Downstream raw materials:

S-[12-(4-benzoylbenzoyloxy)-farnesyl]-cysteine methyl ester

Refernces