methyl 2-((2,6-diisopropylphenyl)amino)-2-oxoacetate

Base Information

• Chemical Name: methyl 2-((2,6-diisopropylphenyl)amino)-2-oxoacetate
• CAS No.: 42022-53-7
• Molecular Formula: C₁₅H₂₁NO₃
• Molecular Weight: 263.337
• Mol file: 42022-53-7.mol

Synonyms:methyl 2-((2,6-diisopropylphenyl)amino)-2-oxoacetate

Chemical Property of methyl 2-((2,6-diisopropylphenyl)amino)-2-oxoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-((2,6-diisopropylphenyl)amino)-2-oxoacetate

There total 3 articles about methyl 2-((2,6-diisopropylphenyl)amino)-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

monomethyl oxalyl chloride (5781-53-3) + 2,6-diisopropylbenzenamine (24544-04-5) → methyl 2-((2,6-diisopropylphenyl)amino)-2-oxoacetate (42022-53-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02830

Reference yield: 78.0%

2,6-diisopropylbenzenamine (24544-04-5) + ethyl oxalylchloride (17118-74-0) → methyl 2-((2,6-diisopropylphenyl)amino)-2-oxoacetate (42022-53-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.joc.0c01147

Reference yield:

2,6-diisopropylbenzenamine (24544-04-5) + pyruvoyl chloride (5704-66-5) → methyl 2-((2,6-diisopropylphenyl)amino)-2-oxoacetate (42022-53-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c03688

upstream raw materials:

monomethyl oxalyl chloride

2,6-diisopropylbenzenamine

ethyl oxalylchloride

pyruvoyl chloride

Downstream raw materials:

2-[(2,6-diisopropylphenyl)amino]-2-oxoacetic acid

2,6-diisopropylphenyl isocyanate

N-(2,6-Diisopropylphenyl)-N'-hydroxyoxamid

Refernces

• 1、 Gediya, Shweta K.,Vyas, Vijyesh K.,Clarkson, Guy J.,Wills, Martin. "Asymmetric Transfer Hydrogenation of α-Keto Amides; Highly Enantioselective Formation of Malic Acid Diamides and α-Hydroxyamides". supporting information. p. 7803 - 7807. Retrieved 2021/10/20.
• 2、 Chinn, Alex J.,Hwang, Jaeyeon,Kim, Byoungmoo,Parish, Craig A.,Krska, Shane W.,Miller, Scott J.. "Application of High-Throughput Competition Experiments in the Development of Aspartate-Directed Site-Selective Modification of Tyrosine Residues in Peptides". supporting information. p. 9424 - 9433. Retrieved 2020/08/14.