17118-74-0

Basic information

• Product Name: 2-oxobutanoyl chloride
• Synonyms: 2-oxobutanoyl chloride;Butanoyl chloride, 2-oxo-
• CAS NO: 17118-74-0
• Molecular Formula: C₄H₅ClO₂
• Molecular Weight: 120.5343
• Mol File: 17118-74-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 158.5±23.0 °C(Predicted)
• Appearance: /
• Density: 1.203±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-oxobutanoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-oxobutanoyl chloride(17118-74-0)
• EPA Substance Registry System: 2-oxobutanoyl chloride(17118-74-0)

Safety Data

• Hazardous Substances Data: 17118-74-0(Hazardous Substances Data)

Upstream product

• 600-18-0 2-Oxobutyric acid 
• 4885-02-3 Dichloromethyl methyl ether 

Downstream Products

• 876760-63-3 1-[(1S,5R,7R)-10,10-Dimethyl-2-oxo-3-(toluene-4-sulfonyl)-3,4-diaza-tricyclo[5.2.1.0^1,5]dec-4-yl]-butane-1,2-dione 
• 1613439-91-0 N-(3-(N,N-dimethylaminocarbonylphenyl))-2-oxobutanamide 
• 886505-59-5 2-(azepan-1-yl)-2-oxoacetic acid 
• 768329-98-2 2-(2,6-dimethylpiperidin-1-yl)-2-oxoacetic acid 
• 17738-71-5 2-((4-chlorophenyl)-amino)-2-oxoacetic acid 
• 49791-37-9 2-oxo-2-(pyrrolidin-1-yl)acetic acid 
• 41374-62-3 2-((4-methoxyphenyl)amino)-2-oxoacetic acid 
• 934489-56-2 2-(dibenzylamino)-2-oxoacetic acid 
• 587-18-8 4-trifluoromethoxy-benzoic acid ethyl ester 
• 42022-53-7 methyl 2-((2,6-diisopropylphenyl)amino)-2-oxoacetate 
• 53117-15-0 ethyl 2-[(3-methoxyphenyl)amino]-2-oxoacetate 
• 18522-99-1 ethyl 4'-methoxyoxanilate 
• 40821-49-6 4-hydroxyphenyl-N-oxamic acid ethyl ester 
• 16703-52-9 2-(dimethylamino)-2-oxoacetic acid ethyl ester 

Relevant articles and documents

A single-step synthesis of xyridins A and B, metabolites from Xyris indica

A facile single-step synthesis of the title isocoumarins isolated from Xyris indica has been elaborated. Condensation of butanoyl chloride and 2-oxobutanoyl chloride with 3,4-methylenedioxyhomophthalic acid afforded xyridin A and xyridin B, respectively. Xyridin A was saponified to the corresponding keto acid, which on reduction gave the (±)-3,4-dihydro-6,7- methylenedioxy-3-propylisocoumarin in which diastereotopy of the methylenic protons around the stereogenic center was observed. A mass fragmentation mechanism for xyridins has also been suggested.

Exploiting the Reactivity of 1,2-Ketoamides: Enantioselective Synthesis of Functionalized Pyrrolidines and Pyrrolo-1,4-benzodiazepine-2,5-diones

A new strategy for the synthesis of optically active pyrrolo[1,4]benzodiazepine-2,5-diones has been developed. The approach is based on an initial Michael addition of functionalized 1,2-ketoamides on nitroalkenes, with a reduction-double cyclization seque

Cationic Ir/Me-BIPAM-catalyzed asymmetric intramolecular direct hydroarylation of α-ketoamides

Asymmetric intramolecular direct hydroarylation of α-ketoamides gives various types of optically active 3-substituted 3-hydroxy-2-oxindoles in high yields with complete regioselectivity and high enantioselectivities (84-98 % ee). This is realized by the use of the cationic iridium complex [Ir(cod) 2](BArF4) and the chiral O-linked bidentate phosphoramidite (R,R)-Me-BIPAM. Carbon's got a brand new bond: Asymmetric intramolecular direct hydroarylation of α-ketoamides gives various optically active 3-substituted 3-hydroxy-2-oxindoles in high yields with complete regioselectivity and high enantioselectivities. This is realized by the use of an asymmetric cationic iridium complex formed in situ (see Scheme).

A temporary-bridge strategy for enantioselective organocatalyzed synthesis of aza-seven-membered rings

We report the first enantioselective organocatalyzed domino synthesis of azepane moieties. This temporary-bridge strategy is based on a conceptually original annulation of ambident electrophilic and 1,4-bis-nucleophilic α-ketoamides with 1,3-bis-electrophilic enals. The obtained oxygen-bridged azepanes can be selectively transformed into optically active azepanone, azepanol or azepanedione derivatives of high synthetic value. This journal is