42022-53-7

Basic information

• Product Name: methyl 2-((2,6-diisopropylphenyl)amino)-2-oxoacetate
• Synonyms: methyl 2-((2,6-diisopropylphenyl)amino)-2-oxoacetate
• CAS NO: 42022-53-7
• Molecular Weight: 263.337
• Mol File: 42022-53-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: methyl 2-((2,6-diisopropylphenyl)amino)-2-oxoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-((2,6-diisopropylphenyl)amino)-2-oxoacetate(42022-53-7)
• EPA Substance Registry System: methyl 2-((2,6-diisopropylphenyl)amino)-2-oxoacetate(42022-53-7)

Safety Data

• Hazardous Substances Data: 42022-53-7(Hazardous Substances Data)

Upstream product

• 24544-04-5 2,6-diisopropylbenzenamine 
• 5704-66-5 pyruvoyl chloride 
• 17118-74-0 ethyl oxalylchloride 
• 5781-53-3 monomethyl oxalyl chloride 

Downstream Products

• 28178-42-9 2,6-diisopropylphenyl isocyanate 
• 42022-38-8 N-(2,6-Diisopropylphenyl)-N'-hydroxyoxamid 
• 169772-26-3 2-[(2,6-diisopropylphenyl)amino]-2-oxoacetic acid 

Relevant articles and documents

Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.

Oxalohydrazide Ligands for Copper-Catalyzed C?O Coupling Reactions with High Turnover Numbers

Here, we report a class of ligands based on oxalohydrazide cores and N-amino pyrrole and N-amino indole units that generates long-lived copper catalysts for couplings that form the C?O bonds in biaryl ethers. These Cu-catalyzed coupling of phenols with aryl bromides occurred with turnovers up to 8000, a value which is nearly two orders of magnitude higher than those of prior couplings to form biaryl ethers and nearly an order of magnitude higher than those of any prior copper-catalyzed coupling of aryl bromides and chlorides. This ligand also led to copper systems that catalyze the coupling of aryl chlorides with phenols and the coupling of aryl bromides and iodides with primary benzylic and aliphatic alcohols. A wide variety of functional groups including nitriles, halides, ethers, ketones, amines, esters, amides, vinylarenes, alcohols and boronic acid esters were tolerated, and reactions occurred with aryl bromides in pharmaceutically related structures.

Reagent Design and Ligand Evolution for the Development of a Mild Copper-Catalyzed Hydroxylation Reaction

Parallel synthesis and mass-directed purification of a modular ligand library, high-throughput experimentation, and rational ligand evolution have led to a novel copper catalyst for the synthesis of phenols with a traceless hydroxide surrogate. The mild reaction conditions reported here enable the late-stage synthesis of numerous complex, druglike phenols.