768329-98-2Relevant articles and documents
Direct C-H Functionalization of Phenanthrolines: Metal- And Light-Free Dicarbamoylations
Demirel, Nemrud,Donkin, Benjamin D. T.,Lee, Ai-Lan,Mooney, David T.,Moore, Peter R.
, p. 17282 - 17293 (2021/12/02)
A direct method for C-H dicarbamoylations of phenanthrolines has been developed, which is capable of directly installing primary, secondary as well as tertiary amides. This is a significant improvement on the previous direct method, which was limited to primary amides. The metal-, light-, and catalyst-free Minisci-type reaction is cheap, operationally simple, and scalable. We demonstrate that the step efficiency toward dicarbamoylated phenanthroline targets can now be significantly improved.