Lophenol

Base Information

• Chemical Name: Lophenol
• CAS No.: 481-25-4
• Molecular Formula: C28H48O
• Molecular Weight: 400.68
• UNII: X4BL075LYS
• DSSTox Substance ID: DTXSID70963996
• Nikkaji Number: J12.379J
• Wikipedia: Lophenol
• Wikidata: Q27103040
• Metabolomics Workbench ID: 34400
• Mol file: 481-25-4.mol

Synonyms:4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol;4-methylcholest-7-en-3-ol;4-methylcholest-7-en-3-ol, (3beta,4alpha)-isomer;methostenol

Chemical Property of Lophenol

Chemical Property:

• Vapor Pressure: 1.51E-11mmHg at 25°C
• Boiling Point: 487.5°C at 760 mmHg
• Flash Point: 213.7°C
• PSA: 20.23000
• Density: 0.98g/cm³
• LogP: 7.63470
• XLogP3: 8.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 400.370516150
• Heavy Atom Count: 29
• Complexity: 620

Purity/Quality:

≥98% （HPLC） ^*data from raw suppliers

Methost-7-enol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1C(CCC2(C1CC=C3C2CCC4(C3CCC4C(C)CCCC(C)C)C)C)O
• Isomeric SMILES: C[C@@H]1[C@H](CC[C@]2([C@H]1CC=C3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4[C@H](C)CCCC(C)C)C)C)O
• Uses: Methost-7-enol has potent inhibitory activity against human cancer cell lines such as liver cancer, nasopharyngeal and colon cancer cells.

Technology Process of Lophenol

There total 16 articles about Lophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

β-sitosterol (83-46-5) → cholest-4α-methyl-7-en-3β-ol (481-25-4) + (3β,4α,5α)-4-methylcholestan-3-ol (3903-57-9) + 4α-methyl-5α-cholesta-7,24-dien-3β-ol + 4α-methyl-5α-cholesta-8(14),24-dien-3β-ol

Guidance literature:

With 25-azacoprostane hydrochloride; In water; at 22 ℃; Yield given. Further byproducts given. Yields of byproduct given; Caenorhabditis elegans, soy peptone, yeast extract, dextrose, casein hydrolyzate, hemoglobin, Tween 80;

DOI:10.1016/0039-128X(83)90042-9

Reference yield:

β-sitosterol (83-46-5) → cholest-4α-methyl-7-en-3β-ol (481-25-4) + 4α-methyl-5α-cholest-8(14)-en-3β-ol (62014-96-4) + (3β,4α,5α)-4-methylcholestan-3-ol (3903-57-9) + 4α-methyl-5α-cholesta-7,24-dien-3β-ol + 4α-methyl-5α-cholesta-8(14),24-dien-3β-ol + 4α-methyl-24ξ-ethyl-5α-cholestan-3β-ol

Guidance literature:

With soy peptone; Tween 80; D-glucose; Caenorhabditis elegans; casein hydrolyzate; 25-azacoprostane hydrochloride; hemoglobin; yeast extract; In water; at 22 ℃; Product distribution; metabolism, further without inhibitor 25-aza-5β-cholestane hydrochloride, <14C>labeled;

DOI:10.1016/0039-128X(83)90042-9

Reference yield:

4α-methyl-5α-cholest-7-en-3-one (2789-43-7) → cholest-4α-methyl-7-en-3β-ol (481-25-4)

Guidance literature:

With lithium aluminium tetrahydride; diethyl ether;

DOI:10.1021/ja01556a033

upstream raw materials:

4α-methyl-5α-cholest-7-en-3-one

β-sitosterol

cholesterol

demosterol

Downstream raw materials:

3β-benzoyloxy-4α-methyl-5α-cholest-7-ene

4α-methyl-5α-cholest-8(14)-en-3β-ol

Refernces