3,4-Dimethylphenylacetic Acid

Base Information

• Chemical Name: 3,4-Dimethylphenylacetic Acid
• CAS No.: 17283-16-8
• Molecular Formula: C10H12O2
• Molecular Weight: 164.204
• Hs Code.: 2916399090
• Mol file: 17283-16-8.mol

Synonyms:Aceticacid, (3,4-xylyl)- (6CI,8CI);2-(3,4-Dimethylphenyl)acetic acid;3,4-Dimethylphenylacetic acid;NSC 165781;

Chemical Property of 3,4-Dimethylphenylacetic Acid

Chemical Property:

• Vapor Pressure: 0.0508mmHg at 25°C
• Refractive Index: 1.503
• Boiling Point: 297.3 °C at 760 mmHg
• Flash Point: 194.4 °C
• PSA: 37.30000
• Density: 1.098 g/cm³
• LogP: 1.93050
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%min ^*data from raw suppliers

(3,4-Dimethylphenyl)aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,4-Dimethylphenylacetic acid, is is used as an intermediate in organic synthesis. It is also used as a fine chemical intermediate.

Technology Process of 3,4-Dimethylphenylacetic Acid

There total 8 articles about 3,4-Dimethylphenylacetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-o-xylene (95-64-7) → 3,4-dimethylphenylacetic acid (17283-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium nitrite; hydrogenchloride; tetrabutyl-ammonium chloride; copper(l) chloride / water / 2 h / -5 - 95 °C

2: hydrogenchloride / 10 h / 80 - 95 °C / Inert atmosphere

With hydrogenchloride; tetrabutyl-ammonium chloride; copper(l) chloride; sodium nitrite; In water;

Reference yield:

1-(2,2,2-trichloroethyl)-3,4-dimethylbenzene (90920-12-0) → 3,4-dimethylphenylacetic acid (17283-16-8)

Guidance literature:

With hydrogenchloride; at 80 - 95 ℃; for 10h; Inert atmosphere;

Reference yield:

3,4-dimethylacetophenone (3637-01-2) → 3,4-dimethylphenylacetic acid (17283-16-8)

Guidance literature:

3,4-dimethylacetophenone; With morpholine; sulfur; at 130 ℃; for 48h;

With sodium hydroxide; water; at 130 ℃; for 24h;

With hydrogenchloride; In water;

DOI:10.1246/bcsj.82.254

upstream raw materials:

diazomethane

3,4-dimethylbenzoyl chloride

3,4-dimethylphenylacetonitrile

3,4-dimethylacetophenone

Downstream raw materials:

N-(2,2-dimethoxyethyl)-3,4-dimethyl-phenylacetamide

1-(3,4-Dimethyl-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline

1-(3,4-dimethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline

N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-(3,4-dimethyl-phenyl)-acetamide

Refernces

• 1、 Usui, Satoshi,Tsuboya, Shoko,Umezawa, Yukthiro,Hazama, Ken,Okamura, Mutsuo. "Exalted resonance demands in the substituent effects on the acetolyses of 2-arylethyl trifluoromethanesulfonates destabilized by cn and cf3 groups". experimental part. p. 254 - 260. Retrieved 2009/05/30.