3637-01-2

Basic information

• Product Name: 3',4'-Dimethylacetophenone
• Synonyms: 1-Acetyl-3,4-dimethylbenzene;Methyl(3,4-xylyl) ketone;3',4'-Dimethylacetophenone,97%;ASISCHEM D29254;3',4'-DIMETHYLACETOPHENONE;3,4-DIMETHYLACETOPHENONE;(3,4-DIMETHYLPHENYL)ETHANONE;1-(3,4-Dimethylphenyl)ethan-1-one
• CAS NO: 3637-01-2
• Molecular Formula: C₁₀H₁₂O
• Molecular Weight: 148.2
• EINECS: 222-859-2
• Product Categories: Ketones;Aromatic Acetophenones & Derivatives (substituted);Adehydes, Acetals & Ketones;C10;Carbonyl Compounds
• Mol File: 3637-01-2.mol
• Article Data: 45

Chemical Properties

• Melting Point: -1.5°C
• Boiling Point: 243 °C(lit.)
• Flash Point: 217 °F
• Appearance: clear colourless to light yellow liquid
• Density: 1.001 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.538(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 907053
• CAS DataBase Reference: 3',4'-Dimethylacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4'-Dimethylacetophenone(3637-01-2)
• EPA Substance Registry System: 3',4'-Dimethylacetophenone(3637-01-2)

Safety Data

• Hazard Codes: Xn
• Statements: 36-20/22
• Safety Statements: 39-26-24/25
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 3637-01-2(Hazardous Substances Data)

Usage

Description

3',4'-Dimethylacetophenone is an organic compound that is characterized as a clear, colorless to light yellow liquid. It is a derivative of acetophenone with two methyl groups attached at the 3' and 4' positions on the phenyl ring. 3',4'-Dimethylacetophenone is known for its distinct chemical properties and is utilized in various applications across different industries.

Uses

Used in Pharmaceutical Industry:
3',4'-Dimethylacetophenone is used as a starting reagent for the synthesis of various pharmaceutical compounds. Specifically, it is employed in the creation of 4-[5-(3,4-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenecarboxyamide, which is a complex molecule with potential applications in the development of new drugs.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3',4'-Dimethylacetophenone serves as an important intermediate compound. Its unique structure allows it to be a valuable building block for the creation of more complex molecules, which can be used in various applications, including the development of new materials, dyes, and other specialty chemicals.
Used in Flavor and Fragrance Industry:
Due to its distinct chemical properties, 3',4'-Dimethylacetophenone can also be used in the flavor and fragrance industry. It can contribute to the development of unique scents and flavors, adding depth and complexity to various products such as perfumes, colognes, and even the food and beverage industry.

Upstream product

• 64-19-7 acetic acid 
• 619-04-5 3,4-dimethylbenzoic acid 
• 506-82-1 dimethylcadmium 
• 21900-23-2 3,4-dimethylbenzoyl chloride 
• 95-47-6 o-xylene 
• 108773-75-7 (3S,4R)-3,4-Bis-(3,4-dimethyl-phenyl)-3,4-dimethyl-[1,2]dioxetane 
• 7446-70-0 aluminium trichloride 
• 89-74-7 2,4-dimethylacetophenone. 
• 7727-15-3 aluminium bromide 
• 108-68-9 3,5-Dimethylphenol 
• 107-06-2 1,2-dichloro-ethane 
• 75-36-5 acetyl chloride 
• 201230-82-2 carbon monoxide 
• 594-27-4 tetramethylstannane 

Downstream Products

• 79219-37-7 1-(3,4-dimethyl-phenyl)-3-piperidino-propan-1-one; hydrochloride 
• 412018-89-4 3-(3,4-dimethyl-phenyl)-2-methyl-butyric acid 
• 871896-99-0 δ-oxy-δ-(3.4-dimethyl-phenyl)-α-amylene 
• 112689-10-8 (3,4-dimethyl-phenyl)-glyoxal-2-oxime 
• 15089-82-4 1-(4,5-dimethyl-2-nitrophenyl)ethanone 
• 49666-83-3 1-(3,4-dimethyl-2-nitro-phenyl)-ethanone 
• 934-80-5 1,2-dimethyl-4-ethylbenzene 
• 91817-69-5 3',4'-dimethylacetophenone oxime 
• 17283-16-8 3,4-dimethylphenylacetic acid 
• 95-64-7 4-amino-o-xylene 
• 619-04-5 3,4-dimethylbenzoic acid 
• 36436-65-4 2-acetyl-4,5-dimethylphenol 
• 56537-78-1 4.5-Dimethyl-3-nitro-acetophenon 

Relevant articles and documents

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Photoinduced Acetylation of Anilines under Aqueous and Catalyst-Free Conditions

A green and efficient visible-light induced functionalization of anilines under mild conditions has been reported. Utilizing nontoxic, cost-effective, and water-soluble diacetyl as photosensitizer and acetylating reagent, and water as the solvent, a variety of anilines were converted into the corresponding aryl ketones, iodides, and bromides. With advantages of environmentally friendly conditions, simple operation, broad substrate scope, and functional group tolerance, this reaction represents a valuable method in organic synthesis.

Metal-Free Photoinduced Transformation of Aryl Halides and Diketones into Aryl Ketones

The acylation of aryl halides to prepare aryl ketones without metal catalyst represents an important yet challenging topic towards more sustainable ketone synthesis. Herein, we describe a simple and efficient metal-free protocol for the acylation of aryl halides with diketone under the irradiation of light utilizing N-methylpiperidine as base under an air atmosphere. This reaction can tolerate a wide range of functional groups and the corresponding ketones can be obtained in modest to good yields.