Technology Process of (S)-1-[2-(Trityl-amino)-acetyl]-pyrrolidine-2-carboxylic acid tert-butyl ester
There total 1 articles about (S)-1-[2-(Trityl-amino)-acetyl]-pyrrolidine-2-carboxylic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
chloro-trimethyl-silane; triethylamine; carbonochloridic acid, butyl ester;
Yield given. Multistep reaction;
1) CH2Cl2-DMFA 2) CH2Cl2.;
DOI:10.1007/BF00598358
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 88 percent / 80percent AcOH / 1 h / 40 °C
2: 1) (CH3)3SiCl; 2) Et3N, butyl chloroformate / 1) CH2Cl2-DMFA; 2) CH2Cl2.
3: 73 percent / hydrogen, Pd black / methanol / 3 h
4: 76 percent / 1) isoamyl nitrite, Et3N, HCl / dioxane; CHCl3; dimethylformamide / 1) 0 to 4 deg C, 12 h; 2) 20-25 deg C, 5 h.
5: 88 percent / CF3COOH, dimethyl sulfide / various solvent(s) / 3 h / 30 °C
With
hydrogenchloride; chloro-trimethyl-silane; dimethylsulfide; hydrogen; palladium; acetic acid; triethylamine; carbonochloridic acid, butyl ester; trifluoroacetic acid; isopentyl nitrite;
In
1,4-dioxane; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1007/BF00598358
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 88 percent / 80percent AcOH / 1 h / 40 °C
2: 1) (CH3)3SiCl; 2) Et3N, butyl chloroformate / 1) CH2Cl2-DMFA; 2) CH2Cl2.
3: 73 percent / hydrogen, Pd black / methanol / 3 h
With
chloro-trimethyl-silane; hydrogen; palladium; acetic acid; triethylamine; carbonochloridic acid, butyl ester;
In
methanol;
DOI:10.1007/BF00598358