8β,14-Dihydroxy-7,8-dihydro Codeinone

Base Information

• Chemical Name: 8β,14-Dihydroxy-7,8-dihydro Codeinone
• CAS No.: 23185-97-9
• Molecular Formula: C₁₈H₂₁NO₅
• Molecular Weight: 331.368
• Mol file: 23185-97-9.mol

Synonyms:8β,14-dihydroxy-7,8-dihydrocodeinone

Chemical Property of 8β,14-Dihydroxy-7,8-dihydro Codeinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 8β,14-Dihydroxy-7,8-dihydrocodeinone is a byproduct of Thebaine (T342450) oxidation.

Technology Process of 8β,14-Dihydroxy-7,8-dihydro Codeinone

There total 4 articles about 8β,14-Dihydroxy-7,8-dihydro Codeinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

14-hydroxycodeinone sulfate → 8α-hydroxyoxycodone (865844-01-5) + Oxycodone (76-42-6) + 14-hydroxycodeinone (508-54-3) + 8β,14-dihydroxy-7,8-dihydrocodeinone (23185-97-9)

Guidance literature:

With formic acid; 5%-palladium/activated carbon; hydrogen; In methanol; water; at 40 ℃; for 1h; under 3102.97 Torr; Overall yield = 84 %; Overall yield = 6.59 g;

Reference yield:

14-hydroxycodeinone sulfate → 8α-hydroxyoxycodone (865844-01-5) + oxycodone sulfate + 14-hydroxycodeinone (508-54-3) + 8β,14-dihydroxy-7,8-dihydrocodeinone (23185-97-9)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In water; at 40 ℃; for 16h; under 3102.97 Torr; Overall yield = 61.8 %; Overall yield = 15.56 g; Sealed tube;

Reference yield:

thebaine (115-37-7) → 8α-hydroxyoxycodone (865844-01-5) + Oxycodone (76-42-6) + 14-hydroxycodeinone (508-54-3) + 8β,14-dihydroxy-7,8-dihydrocodeinone (23185-97-9)

Guidance literature:

thebaine; With formic acid; In water; at 20 - 30 ℃;

With sulfuric acid; dihydrogen peroxide; In water; at 20 ℃; for 16h;

With 5%-palladium/activated carbon; hydrogen; In water; at 20 - 60 ℃; for 20h; Overall yield = 2.33 g;

upstream raw materials:

thebaine

thebaine

Downstream raw materials:

14-hydroxymorphinone

14-hydroxycodeinone

Refernces

• 1、 Proksa, Bohumil. "10-Hydroxythebaine". . p. 369 - 370. Retrieved 2007/10/03.