8α-hydroxyoxycodone

Base Information

• Chemical Name: 8α-hydroxyoxycodone
• CAS No.: 865844-01-5
• Molecular Formula: C₁₈H₂₁NO₅
• Molecular Weight: 331.368
• Mol file: 865844-01-5.mol

Synonyms:8α-hydroxyoxycodone

Chemical Property of 8α-hydroxyoxycodone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8α-hydroxyoxycodone

There total 5 articles about 8α-hydroxyoxycodone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

thebaine (115-37-7) → 8α-hydroxyoxycodone (865844-01-5) + Oxycodone (76-42-6) + 14-hydroxycodeinone (508-54-3)

Guidance literature:

thebaine; With peracetic acid; acetic acid; In water; at -5 - 20 ℃; for 1.5 - 2h;

palladium dihydroxide; In water; at 15 - 20 ℃; for 2h;

With hydrogen; In water; butan-1-ol; at 20 - 25 ℃; for 3h; under 2585.81 Torr; Product distribution / selectivity;

Reference yield:

14-hydroxycodeinone sulfate → 8α-hydroxyoxycodone (865844-01-5) + Oxycodone (76-42-6) + 14-hydroxycodeinone (508-54-3) + 8β,14-dihydroxy-7,8-dihydrocodeinone (23185-97-9)

Guidance literature:

With formic acid; 5%-palladium/activated carbon; hydrogen; In methanol; water; at 40 ℃; for 1h; under 3102.97 Torr; Overall yield = 84 %; Overall yield = 6.59 g;

Reference yield:

14-hydroxycodeinone sulfate → 8α-hydroxyoxycodone (865844-01-5) + oxycodone sulfate + 14-hydroxycodeinone (508-54-3) + 8β,14-dihydroxy-7,8-dihydrocodeinone (23185-97-9)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In water; at 40 ℃; for 16h; under 3102.97 Torr; Overall yield = 61.8 %; Overall yield = 15.56 g; Sealed tube;

upstream raw materials:

thebaine

thebaine

Downstream raw materials:

Oxycodone

oxycodone hydrochloride

Refernces

• 1、 -. "Process for Reducing Impurities in Oxycodone Base". Page/Page column 5-6. . Retrieved 2008/12/05.