Dyclonine hydrochloride

Base Information

• Chemical Name: Dyclonine hydrochloride
• CAS No.: 536-43-6
• Molecular Formula: C18H27NO2^.HCl
• Molecular Weight: 325.879
• Hs Code.: 2933399090
• Mol file: 536-43-6.mol

Synonyms:1-Propanone,1-(4-butoxyphenyl)-3-(1-piperidinyl)-, hydrochloride (9CI);Propiophenone,4'-butoxy-3-piperidino-, hydrochloride (7CI,8CI);4'-Butoxy-3-piperidinopropiophenone hydrochloride;Diclonina;Diclonine;Dyclothane;Tanaclone;

Chemical Property of Dyclonine hydrochloride

Chemical Property:

• Appearance/Colour: White Crystalline Solid
• Vapor Pressure: 2.06E-07mmHg at 25°C
• Melting Point: 175-176 °C
• Boiling Point: 424.5 °C at 760 mmHg
• Flash Point: 210.5 °C
• PSA: 29.54000
• LogP: 4.66410
• Storage Temp.: -20°C Freezer
• Solubility.: Soluble in DMSO (20 mg/ml); Water (25 mg/ml)
• Water Solubility.: Partly soluble in water. Soluble in chloroform, ethanol, acetone and methanol.
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 325.1808568
• Heavy Atom Count: 22
• Complexity: 292

Purity/Quality:

99% ^*data from raw suppliers

Dyclonine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [H+].CCCCOC1=CC=C(C=C1)C(=O)CCN2CCCCC2.[Cl-]
• Description: Dyclonine hydrochloride is the hydrochloride salt of Dyclonine. Dyclonine belongs to a kind of oral anaesthetic. It is contained in the “Sucrets” as well as some kinds of Cepacol sore throat spray as an active ingredient. Dyclonine takes effect through reversibly binding to the activated sodium channels located on the neuronal membrane. This decreases the permeability of sodium across the neuronal membrane, further increasing the threshold for excitation. Overall, Dyclonine stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and further suppressing the subsequent conduction. This causes a transient and reversible anaesthetic effect in a local area of the body. Dyclonine (536-43-6) is a? topical anesthetic which has been used for oral and throat analgesia.1 Enhances neuronal mitochondrial function, potentiating respiration and providing protection against insults associated with neurodegenerative disorders.2 Inhibits aldehyde dehydrogenase ALDH3A1 resulting in accumulation of 4-hydroxynonenal, which renders head and neck squamous cell carcinoma cells sensitive to the cystine-glutamate antiporter inhibitor, sulfasalazine.3 Rescues frataxin deficiency in animal models as well as in buccal cells of patients with Friedreich’s Ataxia.4 Enhances the cytotoxic effect of proteasome inhibitors MG-1325 and bortezomib6 in cancer cells.
• Indications: Dyclonine hydrochloride is a ketone derivative without an ester or amide linkage that may be used in patients who are allergic to the common anesthetics. Dyclonine offers advantages over other topical anesthetic agents.Extensive experience with the topical preparation has shown it to be effective and safe. As a topical anesthetic, dyclonine hydrochloride is available by prescription, and to patients it is available over-the-counter in Sucrets lozenges. Classification: Ketone. Available concentration: Formulated for use in dentistry as a 0.5% or 1% solution. Onset of action: Slow; may take up to 10 minutes to become effective. Duration: Average duration of 30 minutes; however, effects may last up to 1 hour. Maximum recommended dose: 200 mg (40 mL of 0.5% solution or 20 mL of a 1% solution). Metabolism/excretion: No information is available on the metabolism and excretion of dyclonine hydrochloride. Pregnancy/lactation: FDA Category C/Caution is recommended during lactation.
• Uses: Dyclonine hydrochloride is used for the temporary relief of the following occasional mouth and throat symptoms: pain, minor irritation, sore mouth and sore throat. It is a sodium channel blocker and a HSP90 chaperone protein inhibitor. It shows local anesthetic effects in vivo and is orally active. Provides anesthesia of mucous membranes. Apply 5 to 10 minutes before a procedure; apply b.i.d. to t.i.d. for pain relief. Onset of action is within 2 to 10 minutes. Anesthesia lasts 30 to 60 minutes. Used as a local anesthetic
• Therapeutic Function: Local anesthetic

Technology Process of Dyclonine hydrochloride

There total 1 articles about Dyclonine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + piperidine hydrochloride (6091-44-7) + 1-(4-butoxyphenyl)ethan-1-one (5736-89-0) → dyclonine HCl (536-43-6)

Guidance literature:

With ethanol;

Reference yield: 87.0%

dyclonine HCl (536-43-6) → dyclonine (586-60-7)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 10h;

DOI:10.1007/s11164-013-1507-3

Reference yield: 85.0%

dyclonine HCl (536-43-6) → C18H28N2O2

Guidance literature:

With formic acid; nitromethane; trifluoromethylsulfonic anhydride; In acetic acid; at 100 ℃; for 12h;

DOI:10.1126/science.aay9501

upstream raw materials:

formaldehyd

piperidine hydrochloride

1-(4-butoxyphenyl)ethan-1-one

Downstream raw materials:

1-(4-Butoxyphenyl)-2-propen-1-one

dyclonine