M-Toluidine hydrochloride

Base Information

• Chemical Name: M-Toluidine hydrochloride
• CAS No.: 638-03-9
• Molecular Formula: C7H9 N . Cl H
• Molecular Weight: 143.616
• Hs Code.: 2923900090
• European Community (EC) Number: 211-314-4
• UNII: 66SF181V4S
• DSSTox Substance ID: DTXSID2021363
• Wikidata: Q27264023
• ChEMBL ID: CHEMBL3188175
• Mol file: 638-03-9.mol

Synonyms:M-TOLUIDINE HYDROCHLORIDE;638-03-9;m-Toluidine HCl;3-Methylaniline hydrochloride;m-Toluidine.HCl;m-Toluidinium chloride;m-Toluidine, hydrochloride;CCRIS 6103;DTXSID2021363;EINECS 211-314-4;Benzenamine, 3-methyl-, hydrochloride;UNII-66SF181V4S;66SF181V4S;m-aminotoluene hydrochloride;3-methylaniline;hydrochloride;DTXCID701363;SCHEMBL2477661;CHEMBL3188175;Aniline,3-methyl-, hydrochloride;Tox21_200215;MFCD00070607;AKOS016367425;LS-1537;SB75381;NCGC00257769-01;AS-58518;CAS-638-03-9;CS-0153216;FT-0714622;T0301;Benzenamine, 3-methyl-, hydrochloride (9CI);D97463;Q27264023

Chemical Property of M-Toluidine hydrochloride

Chemical Property:

• Appearance/Colour: light grey solid
• Melting Point: 228 C
• Refractive Index: 1.5760 (estimate)
• Boiling Point: 250 C (?)
• PSA: 26.02000
• Density: 1.0968 (rough estimate)
• LogP: 2.96040
• Water Solubility.: Soluble in water
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 143.0501770
• Heavy Atom Count: 9
• Complexity: 70.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

m-Toluidine Hydrochloride >98.0%(GC)(N) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC=C1)N.Cl

Technology Process of M-Toluidine hydrochloride

There total 12 articles about M-Toluidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-methyl-3-nitrobenzene (99-08-1) → m-toluidine hydrochloride (638-03-9)

Guidance literature:

1-methyl-3-nitrobenzene; With hydrogen; In ethanol; at 25 ℃; under 11172.7 Torr; Flow reactor;

With hydrogenchloride; In ethanol; chemoselective reaction; Flow reactor;

DOI:10.1039/c5ra07563g

Reference yield: 45.0%

{2-Methoxy-6-[(E)-m-tolylimino-methyl]-8,9-dihydro-7H-benzocyclohepten-5-yl}-m-tolyl-amine; hydrochloride (74234-59-6) → m-toluidine hydrochloride (638-03-9) + 3-Methoxy-11-methyl-6,7-dihydro-5H-13-aza-benzo[3,4]cyclohepta[1,2-b]naphthalene (74234-50-7)

Guidance literature:

DOI:10.1055/s-1980-29014

Reference yield:

1-amino-3-methylbenzene (108-44-1) → 3'-methyl-2,4-dinitrodiphenylamine (964-79-4) + m-toluidine hydrochloride (638-03-9)

Guidance literature:

With 1-chloro-2,4-dinitro-benzene; In 1,4-dioxane; water; at 45 ℃; for 0.5h;

upstream raw materials:

ethanol

1-phenyl-1-m-toluidino-pentan-3-one

phenylhydrazine hydrochloride

1-methyl-3-nitrobenzene

Downstream raw materials:

N⁴-m-tolyl-pyrimidine-4,6-diyldiamine

N-ethyl-m-toulidine

N,N-diethyl-m-toluidine

2-(3-m-tolyl-triazenyl)-benzoic acid methyl ester

Refernces

• 1、 Osako, Takao,Torii, Kaoru,Tazawa, Aya,Uozumi, Yasuhiro. "Continuous-flow hydrogenation of olefins and nitrobenzenes catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer". . p. 45760 - 45766. Retrieved 2015/06/08.
• 2、 Ficker, Mario,Petersen, Johannes F.,Hansen, Jon S.,Christensen, Jorn B.. "Hydrogenation of aromatic nitro compounds with an inexpensive and efficient CuSO4/CoCl2 catalyst prepared in situ using NaBH 4 as the hydrogen source". . p. 176 - 182. Retrieved 2014/04/17.