4-(Bromomethyl)-2,2-dimethyl-1,3-dioxalane

Base Information

• Chemical Name: 4-(Bromomethyl)-2,2-dimethyl-1,3-dioxalane
• CAS No.: 36236-76-7
• Molecular Formula: C6H11BrO2
• Molecular Weight: 195.056
• Hs Code.: 2932999099
• Mol file: 36236-76-7.mol

Synonyms:5-bromomethyl-2,2-dimethyl-1,3-dioxolane;1-bromo-1-deoxy-2,3-isopropylidene-rac-glycerol;

Chemical Property of 4-(Bromomethyl)-2,2-dimethyl-1,3-dioxalane

Chemical Property:

• Vapor Pressure: 0.688mmHg at 25°C
• Refractive Index: 1.4597 (589.3 nm 20℃)
• Boiling Point: 192.2°C at 760 mmHg
• Flash Point: 74.8°C
• PSA: 18.46000
• Density: 1.359g/cm³
• LogP: 1.53280
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-(Bromomethyl)-2,2-dimethyl-1,3-dioxolane 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Bromomethyl)-2,2-dimethyl-1,3-dioxalane

There total 10 articles about 4-(Bromomethyl)-2,2-dimethyl-1,3-dioxalane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.2%

acetone (67-64-1) + 1,2-Epoxy-3-bromopropane (3132-64-7,82584-73-4) → 4-(bromomethyl)-2,2-dimethyl-1,3-dioxolane (36236-76-7)

Guidance literature:

With tin(IV) chloride; In tetrachloromethane; for 2.5h; Ambient temperature;

DOI:10.1248/cpb.32.967

Reference yield: 53.5%

1-bromo-2,3-propanediol (4704-77-2) + acetone (67-64-1) → 4-(bromomethyl)-2,2-dimethyl-1,3-dioxolane (36236-76-7)

Guidance literature:

With sulfuric acid; for 24h; Ambient temperature;

DOI:10.1021/jm00165a016

Reference yield:

→ (R)-4-bromomethyl-2,2-dimethyl-[1,3]dioxolane (14437-87-7,34637-20-2,36236-76-7,113428-57-2)

Guidance literature:

Verb. I, Acn., LiBr;

DOI:10.1016/S0040-4039(00)70074-8

upstream raw materials:

Bromodiphenylmethane

1-bromo-2,3-propanediol

2,2-dimethoxy-propane

acetone

Downstream raw materials:

2-(4-Isobutyl-phenyl)-propionic acid 1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-piperidin-4-yl ester

3-benziloyloxy-1-(2,2-dimethyl-1,3-dioxolan-4ylmethyl)piperidine

4-benziloyloxy-1-(2,2-dimethyl-1,3-dioxolan-4-ylmethyl)piperidine

Hydroxy-phenyl-acetic acid 1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-piperidin-4-yl ester

Refernces

• 1、 -. "NOVEL COMPOUNDS, FUNCTIONALISED DIOXABOROLANE OR DIOXABORINANE DERIVATIVES, METHOD FOR PREPARING SAME AND USES THEREOF". Paragraph 0307-0309. . Retrieved 2020/08/05.
• 2、 -. "BIPHENYL CARBOXYLIC AMIDE P38 KINASE INHIBITORS". Page 43. . Retrieved 2008/06/13.