4-HYDROXY-2-METHOXY-BENZOIC ACID

Base Information

• Chemical Name: 4-HYDROXY-2-METHOXY-BENZOIC ACID
• CAS No.: 90111-34-5
• Molecular Formula: C8H8 O4
• Molecular Weight: 168.149
• Hs Code.: 2918990090
• Mol file: 90111-34-5.mol

Synonyms:o-Anisicacid, 4-hydroxy- (7CI); 4-Hydroxy-2-methoxybenzoic acid; Pluchoic acid

Chemical Property of 4-HYDROXY-2-METHOXY-BENZOIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 369.383°C at 760 mmHg
• Flash Point: 156.796°C
• PSA: 66.76000
• Density: 1.352g/cm³
• LogP: 1.09900
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%min ^*data from raw suppliers

4-Hydroxy-2-methoxybenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Hydroxy-2-methoxybenzoic Acid is used in preparation of sulfonamide compound for induction of targeted protein degradation.

Technology Process of 4-HYDROXY-2-METHOXY-BENZOIC ACID

There total 16 articles about 4-HYDROXY-2-METHOXY-BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-hydroxy-2-methoxybenzaldehyde (18278-34-7) → 4-hydroxy-2-methoxybenzoic acid (90111-34-5)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; In water; dimethyl sulfoxide; at 0 - 20 ℃; for 6h;

Reference yield: 95.0%

methyl 4-hydroxy-2-methoxybenzoate (28478-46-8) → 4-hydroxy-2-methoxybenzoic acid (90111-34-5)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1016/S0960-894X(98)00568-X

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + diethyl ether (60-29-7,927820-24-4) + 2,4-bis(acetyloxy)benzoic acid (51-01-4) → 4-methoxysalicylic acid (2237-36-7) + 4-hydroxy-2-methoxybenzoic acid (90111-34-5)

Guidance literature:

Erhitzen des Reaktionsprodukts mit wss. Alkalilauge;

DOI:10.1021/ja01373a036

upstream raw materials:

4-acetoxy-2-methoxy-benzaldehyde

4-Methoxycarbonyloxy-2-methoxybenzoesaeure-methylester

methyl 4-hydroxy-2-methoxybenzoate

diazomethane

Downstream raw materials:

methyl 2, 4-dimethoxybenzoate

1-[1-(4-Hydroxy-2-methoxy-benzoyl)-piperidin-4-yl]-1,4-dihydro-benzo[d][1,3]oxazin-2-one

(+/-)-1-{1-[4-(1-{piperidin-4-yl}ethoxy)-2-methoxybenzoyl]-piperidin-4-yl}-4H-3,1-benzoxazin-2(1H)-one

Refernces

• 1、 -. "COMPOUNDS AND THEIR USES AS MIF INHIBITORS". Paragraph 0309. . Retrieved 2022/01/08.
• 2、 -. "PHARMACEUTICAL COMPOUNDS". Page/Page column 94; 151. . Retrieved 2015/09/23.