2,3-DIMETHOXYPHENYLACETIC ACID

Base Information

• Chemical Name: 2,3-DIMETHOXYPHENYLACETIC ACID
• CAS No.: 90-53-9
• Molecular Formula: C10H12O4
• Molecular Weight: 196.203
• Hs Code.: 2918990090
• Mol file: 90-53-9.mol

Synonyms:Aceticacid, (2,3-dimethoxyphenyl)- (6CI,8CI);2-(2,3-Dimethoxyphenyl)acetic acid;NSC 12232;o-Homoveratric acid;

Chemical Property of 2,3-DIMETHOXYPHENYLACETIC ACID

Chemical Property:

• Vapor Pressure: 0.000154mmHg at 25°C
• Melting Point: 82-84 °C
• Refractive Index: 1.527
• Boiling Point: 318.2 °C at 760 mmHg
• PKA: 4.03±0.10(Predicted)
• Flash Point: 123.9 °C
• PSA: 55.76000
• Density: 1.189 g/cm³
• LogP: 1.33090
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

96% 1H NMR ^*data from raw suppliers

o-HomoveratricAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: o-Homoveratric Acid is a metabolite of hydroxylated phenylalkylamines.

Technology Process of 2,3-DIMETHOXYPHENYLACETIC ACID

There total 14 articles about 2,3-DIMETHOXYPHENYLACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(2,3-dimethoxyphenyl)acetonitrile (4468-57-9) → 2,3-dimethoxyphenylacetic acid (90-53-9)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 10h; Heating;

DOI:10.1002/hlca.200390036

Reference yield:

2,3-dimethoxybenzyl chloride (3893-01-4) → 2,3-dimethoxyphenylacetic acid (90-53-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / ethanol; H₂O / 1 h / Heating

2: 90 percent / NaOH / H₂O; ethanol / 10 h / Heating

With sodium hydroxide; In ethanol; water;

DOI:10.1002/hlca.200390036

Reference yield:

2,3-dimethoxybenzyl alcohol (5653-67-8) → 2,3-dimethoxyphenylacetic acid (90-53-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / SOCl₂; pyridine / CHCl₃ / 0.75 h / 20 °C

2: 99 percent / ethanol; H₂O / 1 h / Heating

3: 90 percent / NaOH / H₂O; ethanol / 10 h / Heating

With pyridine; sodium hydroxide; thionyl chloride; In ethanol; chloroform; water;

DOI:10.1002/hlca.200390036

upstream raw materials:

2-(2,3-dimethoxyphenyl)acetonitrile

1-allyl-2,3-dimethoxy-benzene

2-(2,3-dimethoxyphenyl)-2-hydroxyacetonitrile

(2-hydroxy-3-methoxy-phenyl)-acetic acid

Downstream raw materials:

(2R,4S)-4-(benzyloxy)hept-6-en-2-ol 2-(3,5-dimethoxyphenyl)acetate

(2,3-dimethoxyphenyl)acetaldehyde

Refernces

• 1、 McNulty, James,Das, Priyabrata. "Development of a one-pot method for the homologation of aldehydes to carboxylic acids". experimental part. p. 7794 - 7800. Retrieved 2009/12/26.
• 2、 Ahmad,Snieckus. "A convenient entry into the rhoeadan skeleton. Total synthesis of (±)-cis-alpinigenine". . p. 2678 - 2686. Retrieved 2007/10/02.