Multi-step reaction with 10 steps
1.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 72 h / 0 - 20 °C
2.1: potassium carbonate / dichloromethane / 3 h / 0 - 20 °C
3.1: potassium tert-butylate; tert-butyl alcohol / 0.5 h / Reflux
4.1: Lawessons reagent / tetrahydrofuran / 2 h / 20 °C / Reflux
5.1: tert.-butylhydroperoxide; ammonium hydroxide; ammonia / water; methanol / 20 °C
6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 0 - 20 °C
7.1: sodium L-ascorbate; copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; sodium azide / water; ethanol / 4 h / 90 °C / Inert atmosphere
8.1: hydrogen / ethyl acetate / 10 h / 20 °C
9.1: n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere
9.2: 0.5 h / -78 °C
10.1: trifluoroacetic acid / dichloromethane / 0.33 h / 5 °C
With
Lawessons reagent; tert.-butylhydroperoxide; ammonium hydroxide; sodium tetrahydroborate; copper(l) iodide; n-butyllithium; sodium azide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; boron trifluoride diethyl etherate; potassium tert-butylate; ammonia; hydrogen; potassium carbonate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tert-butyl alcohol;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate;